M3949

MST-312

≥98% (HPLC)

• Synonym(e): N,N′-1,3-Phenylenebis-[2,3-dihydroxy-benzamide]
• Empirische Formel (Hill-System): C₂₀H₁₆N₂O₆
• CAS-Nummer: 368449-04-1
• Molekulargewicht: 380.35
• MDL-Nummer: MFCD24368986
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 329817985
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: off-white to light tan
• Löslichkeit: DMSO: ≥20 mg/mL
• Lagertemp.: 2-8°C
• SMILES String: Oc1cccc(C(=O)Nc2cccc(NC(=O)c3cccc(O)c3O)c2)c1O
• InChI: 1S/C20H16N2O6/c23-15-8-2-6-13(17(15)25)19(27)21-11-4-1-5-12(10-11)22-20(28)14-7-3-9-16(24)18(14)26/h1-10,23-26H,(H,21,27)(H,22,28)
• InChIKey: MIQUEZGHEJGPJB-UHFFFAOYSA-N

Beschreibung

Anwendung

MST-312 has been used in cell invasion assay using mouse fibroblast cells (NIH-3T3) and in the co-immunoprecipitation experiments in colon fibroblast.

Biochem./physiol. Wirkung

MST-312 is a telomerase Inhibitor. Telomeres are nucleoprotein complexes present on the ends of chromosomes, containing DNA segment tandem repeats that shorten with each repetitive cell cycle. Telomere shortening leads to loss of function, resulting in cell senescence and limited survivability. The reverse transcriptase, telomerase, maintains telomere length and function in immortalized cell lines and most cancer cell lines, and telomerase activity is associated with tumorigenesis. Telomere elongation is also believed to be an important contributor to the genomic stability and indefinite self renewal of iPS cells. 1 μM MST-312 was shown to effectively reduce telomere length and inhibit proliferation in U937 cells.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 2
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable