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Ursprungszeugnis (CoO)/Analysenzertifikate (CoA)

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M2922

3-Methyl-6-[3-(trifluoromethyl)phenyl]-1,2,4-triazolo[4,3-b]pyridazine

Name: 3-Methyl-6-[3-(trifluoromethyl)phenyl]-1,2,4-triazolo[4,3-b]pyridazine
Brand: SIGMA

Synonym(e):

CL 218,872

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About This Item

Empirische Formel (Hill-System):

C₁₃H₉F₃N₄

CAS-Nummer:

66548-69-4

Molekulargewicht:

278.23

MDL-Nummer:

MFCD00674912

UNSPSC-Code:

12352200

PubChem Substanz-ID:

24278545

Lagertemp.

2-8°C

SMILES String

Cc1nnc2ccc(nn12)-c3cccc(c3)C(F)(F)F

Angaben zum Gen

human ... BZRAP1(9256) , GABRA1(2554) , GABRA2(2555) , GABRA3(2556) , GABRA5(2558) , GABRA6(2559) , GABRG2(2566)

Biochem./physiol. Wirkung

Selective agonist at the BZ_I benzodiazepine receptor.

Piktogramme

GHS07

Signalwort

Warning

H-Sätze

H315,H319,H335

P-Sätze

P261 - P305 + P351 + P338

Gefahreneinstufungen

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

dust mask type N95 (US), Eyeshields, Gloves

Hier finden Sie alle aktuellen Versionen:

Analysenzertifikate (COA)

Lot/Batch Number

066H4130

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CL 218,872 a triazolopyridazine with a selective affinity for the benzodiazepine BZ1 receptor subtype, retards the development and expression of amygdaloid-kindled seizures: effects of flumazenil.

R K McNamara et al.

Epilepsy research, 16(1), 19-26 (1993-09-01)

To clarify the role of benzodiazepine receptors in kindling, the present experiment assessed the effects of CL 218,872 (1, 5, 10, and 20 mg/kg), a triazolopyridazine with a selective affinity for the putative benzodiazepine BZ1 receptor subtype, on the development

Bicyclic [b]-heteroannulated pyridazine derivatives--II. Structure-activity relationships in the 6-aryltriazolo-[4,3-b]pyridazine ligands of the benzodiazepine receptor.

J Karolak-Wojciechowska et al.

Bioorganic & medicinal chemistry, 2(8), 773-779 (1994-08-01)

Electronic parameters (molecular electrostatic potential MEP, charge distribution on the nitrogen atoms, dipole moment mu and ionization potential IP) were calculated by semiempirical quantum chemistry methods for 2 sets (X = H and m-CF3, the syn- and anti-rotamers of the

Differences in expression of GABAA receptor subunits, but not benzodiazepine binding, in the chick brainstem auditory system.

R L Hyson et al.

Journal of molecular neuroscience : MN, 8(3), 193-205 (1997-06-01)

Neurons in nucleus magnocellularis (NM) and nucleus laminaris (NL) of the chick brainstem auditory system show an unusual physiological response to GABA. Examination of these nuclei using in situ hybridization for GABAA receptor subunits showed a differential expression of the

Potentiation of gamma-aminobutyric acid-induced chloride currents by various benzodiazepine site agonists with the alpha 1 gamma 2, beta 2 gamma 2 and alpha 1 beta 2 gamma 2 subtypes of cloned gamma-aminobutyric acid type A receptors.

H K Im et al.

Molecular pharmacology, 44(4), 866-870 (1993-10-01)

Previous studies with cloned gamma-aminobutyric acid type A receptors expressed in human embryonic kidney cells have indicated that the alpha 1 beta 2 gamma 2 and alpha 1 gamma 2 (but not alpha 1 beta 2) subtypes have benzodiazepine sites.

Coincidental appearance of the alpha 1 subunit of the GABA-A receptor and the type I benzodiazepine receptor near birth in macaque monkey visual cortex.

A Hendrickson et al.

International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 12(4), 299-314 (1994-06-01)

The expression of subtypes of the GABA-A/benzodiazepine receptor complex has been studied during pre- and postnatal development of Macaca monkey visual cortex using complementary radioligand and immunocytochemical labeling. Type I benzodiazepine receptors were labeled directly by [3H]zolpidem. Type II receptors

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