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L0649

Sigma-Aldrich

Leupeptin hydrochloride

powder, ≥70% (HPLC)

Synonym(e):

Acetyl-Leu-Leu-Arg-al -hydrochlorid

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About This Item

Empirische Formel (Hill-System):
C20H38N6O4 · HCl
CAS-Nummer:
24125-16-4
Molekulargewicht:
463.01
MDL-Nummer:
MFCD00133457
UNSPSC-Code:
12352202
PubChem Substanz-ID:
24896263
NACRES:
NA.77

product name

Leupeptin hydrochloride, microbial, ≥70% (HPLC)

Biologische Quelle

microbial

Qualitätsniveau

200

Assay

≥70% (HPLC)

Form

powder

Löslichkeit

water: 50 mg/mL, clear, colorless to yellow

Lagertemp.

−20°C

SMILES String

Cl.CC(C)CC(NC(C)=O)C(=O)NC(CC(C)C)C(=O)NC(CCCNC(N)=N)C=O

InChI

1S/C20H38N6O4.ClH/c1-12(2)9-16(24-14(5)28)19(30)26-17(10-13(3)4)18(29)25-15(11-27)7-6-8-23-20(21)22;/h11-13,15-17H,6-10H2,1-5H3,(H,24,28)(H,25,29)(H,26,30)(H4,21,22,23);1H

InChIKey

OQQYPQNFLLAILR-UHFFFAOYSA-N

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Verwandte Kategorien

Biochem./physiol. Wirkung

Inhibitor of serine and cysteine proteases. Inhibits plasmin, trypsin, papain, calpain, and cathepsin B. Does not inhibit pepsin, cathepsins A and D, thrombin, or α-chymotrypsin. Effective concentration 10-100 μM. There have been numerous studies using leupeptin to protect against hearing loss caused by acoustic overstimulation or the ototoxic antibiotic gentamicin. (Loss of cochlear hair cells is believed to be mediated by calpain.)

Hinweis zur Analyse

Leupeptin gives multiple peaks on HPLC because of the formation of tautomeric isomers in solution. Majority of contaminating peptide is racemized leupeptin.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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