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K2768

Sigma-Aldrich

KHS1, active, GST tagged human

PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

Synonym(e):

GCKR, MAP4K5, MAPKKKK5

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About This Item

UNSPSC-Code:
12352204
NACRES:
NA.32

Rekombinant

expressed in baculovirus infected Sf9 cells

Qualitätsniveau

200

Produktlinie

PRECISIO® Kinase

Assay

≥70% (SDS-PAGE)

Form

buffered aqueous glycerol solution

Spezifische Aktivität

76-99 nmol/min·mg

Mol-Gew.

~135 kDa

UniProt-Hinterlegungsnummer

Q9Y4K4

Versandbedingung

dry ice

Lagertemp.

−70°C

Angaben zum Gen

human ... MAP4K5(11183)

Biochem./physiol. Wirkung

KHS1 (kinase homologous to SPS1/STE20) is a component of MAP (mitogen activated protein) kinase signaling pathway and is responsible for activation of JUNK (c-Jun N-terminal kinase). Mutation in the promoter region of KHS1 is linked with lower risk of type 2 diabetes.[1] It is also referred to as MAP4K5 (mitogen-activated protein kinase kinase kinase kinase 5)

Physikalische Form

Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.2 5mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.

Rechtliche Hinweise

PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany

Lagerklassenschlüssel

10 - Combustible liquids

WGK

WGK 1

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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Analysenzertifikate (COA)

Lot/Batch Number

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Maura Epifanía Matus-Ortega et al.
Biochimica et biophysica acta, 1769(3), 194-203 (2007-03-06)
PNPase is a phosphate-dependent exonuclease of Escherichia coli required for growth in the cold. In this work we explored the effect of specific mutations in its two RNA binding domains KH and S1 on RNA binding, enzymatic activities, autoregulation and
Yanyun Gu et al.
Journal of human genetics, 51(7), 605-610 (2006-05-16)
MAP4K5 (mitogen-activated protein kinase kinase kinase kinase 5), an early component of MAP kinase signal cascades was shown to activate Jun kinase in mammalian cells. The association between SNPs of MAP4K5 and type 2 diabetes (T2DM) was investigated due to
C S Shi et al.
Journal of immunology (Baltimore, Md. : 1950), 163(6), 3279-3285 (1999-09-08)
TNF-induced activation of stress activated protein kinases (SAPKs, Jun NH2-terminal kinases) requires TNF receptor associated factor 2 (TRAF2). TRAF2 is a potent activator of a 95-kDa serine/threonine kinase termed germinal center kinase related (GCKR, also referred to as KHS1), which

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