I7160

IMS2186

≥98% (HPLC), solid

• Synonym(e): 3-[1-(3-Hydroxy-4-methoxyphenyl)-meth-(E)-ylidene]-6-methyl-chroman-4-one
• Empirische Formel (Hill-System): C₁₈H₁₆O₄
• CAS-Nummer: 1031206-36-6
• Molekulargewicht: 296.32
• MDL-Nummer: MFCD12912419
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 329815315
• NACRES: NA.77

Eigenschaften

• Assay: ≥98% (HPLC)
• Form: solid
• Lagerbedingungen: desiccated
• Farbe: white to off-white
• Löslichkeit: DMSO: >20 mg/mL
• Lagertemp.: room temp
• SMILES String: COc1ccc(cc1O)\C=C2/COc3ccc(C)cc3C2=O
• InChI: 1S/C18H16O4/c1-11-3-5-16-14(7-11)18(20)13(10-22-16)8-12-4-6-17(21-2)15(19)9-12/h3-9,19H,10H2,1-2H3/b13-8+
• InChIKey: BZCADTHMZLYKAR-MDWZMJQESA-N

Beschreibung

Biochem./physiol. Wirkung

IMS2186 is an anti-proliferative and anti-angiogenic agent. Apparently IMS2186 blocks the cell cycle at G2 and inhibits the production of PGE2/TNF-α. IMS2186 inhibits cell growth in vitro in tumor cells, non-transformed fibroblasts, and retinal pigment epithelial cells. IMS2186 inhibits angiogenesis (IC₅₀ = 0.1 μM) and cell migration. Intraocular injection of IMS2186 could be a long-lasting effective treatment for CNV (choroidal neovascularization) in AMD (age-related macular degeneration) with a reduction in scarring and related visual loss.

Sicherheitshinweise

• Piktogramme: GHS09
• Signalwort: Warning
• H-Sätze: H410
• P-Sätze: P273 - P391 - P501
• Gefahreneinstufungen: Aquatic Acute 1 - Aquatic Chronic 1
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Gloves