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I5782

Sigma-Aldrich

Anti-Interleukin-22 Receptor, C-Terminal antibody produced in rabbit

~0,5 mg/mL, affinity isolated antibody, buffered aqueous solution

Synonym(e):

Anti-IL-22R

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About This Item

MDL-Nummer:
MFCD04040428
UNSPSC-Code:
51111800

Biologische Quelle

rabbit

Konjugat

unconjugated

Antikörperform

affinity isolated antibody

Antikörper-Produkttyp

primary antibodies

Klon

polyclonal

Form

buffered aqueous solution

Mol-Gew.

antigen ~62 kDa

Speziesreaktivität

human

Konzentration

~0,5 mg/mL

Methode(n)

western blot: 0.5-1 μg/mL

UniProt-Hinterlegungsnummer

Q8N6P7

Versandbedingung

dry ice

Lagertemp.

−20°C

Posttranslationale Modifikation Target

unmodified

Angaben zum Gen

human ... IL22RA1(58985)

Immunogen

synthetic peptide corresponding to amino acids 560-574 of human IL-22 receptor precursor.

Biochem./physiol. Wirkung

Interleukin-22 (IL-22) belongs to the IL-10 family of T-cell associated cytokines, highly expressed by Th17 cell subset and also by cells of innate immunity system. The cellular effects of IL-22 are mediated by a heterodimeric receptor made up of IL-22 and IL-10Rβ. IL-22 signaling mediates proliferation of epithelial cells during inflammation mainly by the activation of STAT1 and STAT3 signaling.

Leistungsmerkmale und Vorteile

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physikalische Form

Solution in phosphate buffered saline containing 0.02% sodium azide.

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Shomyseh Sanjabi et al.
Current opinion in pharmacology, 9(4), 447-453 (2009-06-02)
Cytokines play a major role in maintaining lymphocyte homeostasis under both steady-state and inflammatory conditions. Unregulated lymphocytes in steady-state conditions can lead to autoimmunity, whereas during inflammation they can cause excessive tissue damage. Regulatory cytokines function in combination with other
Lauren A Zenewicz et al.
European journal of immunology, 38(12), 3265-3268 (2008-11-20)
IL-22 is a Th17 T-cell-associated cytokine that is highly expressed during chronic inflammation. IL-22 receptor expression is absent on immune cells, but is instead restricted to the tissues, providing signaling directionality from the immune system to the tissues. Through Stat3
M H Xie et al.
The Journal of biological chemistry, 275(40), 31335-31339 (2000-07-06)
We report the identification of a novel human cytokine, distantly related to interleukin (IL)-10, which we term IL-22. IL-22 is produced by activated T cells. IL-22 is a ligand for CRF2-4, a member of the class II cytokine receptor family.

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