I2765

Ibotenic acid

~95% (TLC), solid, neurotoxin

• Synonym(e): α-Amino-3-hydroxy-5-isoxazoleacetic acid
• Empirische Formel (Hill-System): C₅H₆N₂O₄
• CAS-Nummer: 2552-55-8
• Molekulargewicht: 158.11
• MDL-Nummer: MFCD00069294
• UNSPSC-Code: 12352209
• PubChem Substanz-ID: 24277994
• NACRES: NA.32

Eigenschaften

• product name: Ibotenic acid, ~95%, solid
• Assay: ~95%
• Qualitätsniveau: 100
• Form: solid
• Farbe: white
• Löslichkeit: H₂O: 1 mg/mL, clear, colorless (with sonication); 0.1 M NaOH: 10.7 mg/mL; 0.1 M HCl: 4.7 mg/mL
• SMILES String: NC(C(O)=O)C1=CC(=O)NO1
• InChI: 1S/C5H6N2O4/c6-4(5(9)10)2-1-3(8)7-11-2/h1,4H,6H2,(H,7,8)(H,9,10)
• InChIKey: IRJCBFDCFXCWGO-UHFFFAOYSA-N
• Angaben zum Gen: rat ... Grm1(24414) , Grm2(24415)

Beschreibung

Anwendung

Ibotenic acid has been used as a neurontoxin in rats. It has also been used in inducing a primary permanent lesion monkey cortex M1 neurons.

Ibotenic acid has been used to perform surgery in adult male zebra finches (Taeniopygia guttata) to study reversing reinforcement-induced vocal changes.

Biochem./physiol. Wirkung

Ibotenic acid is an analog of glutamate. It is involved in the excitation of cell bodies and destroys the thalamic reticular nucleus (NRT). It induces high calcium influx leading to neuronal injury. Ibotenic acid is used to induce neurodegeneration due to its excitotoxic functionality.

Non-selective agonist with preference for NMDA glutamate receptors; neurotoxin; neuroexcitatory amino acid originally isolated from Amanita species.

Vorsicht

Hygroscopic

Sicherheitshinweise

• Piktogramme: GHS06
• Signalwort: Danger
• H-Sätze: H301
• P-Sätze: P301 + P310 + P330
• Gefahreneinstufungen: Acute Tox. 3 Oral
• Lagerklassenschlüssel: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges