Phosphodiesterase IV (PDE4) inhbitor. Inhibits platelet aggregation. Anti-asthma drug.
Leistungsmerkmale und Vorteile
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Journal of neurotrauma, 29(3), 600-610 (2011-08-03)
Ibudilast, an asthma drug, has demonstrated antinociceptive effects in several rat models of peripheral neuropathic pain, and a proposed mechanism of action is the inhibition of release of the cytokine tumor necrosis factor-α (TNF-α) from activated spinal microglia. Spinal glial
Ibudilast (3-isobutyryl-2-isopropylpyrazolo[1,5-alpha]pyridine) is clinically used as a cerebral vasodilator in Japan. However, the effects of ibudilast on retinal blood vessels have not been fully examined. The aim of this study, therefore, was to examine the effects of ibudilast on retinal
Ibudilast is a phosphodiesterase inhibitor influencing inflammation and neurodegeneration in multiple sclerosis (MS). This study evaluated the safety, tolerability, and effects on MRI parameters of 2 different doses of ibudilast in relapsing forms of MS. In this multicenter, double-blind, phase
Primary neuroprotection: the Holy Grail of multiple sclerosis therapy.
Human Immunodeficiency Virus-1 (HIV-1)-associated neurocognitive disorders (HAND) occur, in part, due to the inflammatory response to viral proteins, such as the HIV-1 transactivator of transcription (Tat), in the central nervous system (CNS). Given the need for novel adjunctive therapies for
Hello! I need to know whether I can prepare the working solution of the Ibudilast powder by diluting it in DMSO and freezing for storage at -20C. Will the compound be not degraded or damaged after freezing?
However, solutions in DMSO or ethanol may be stored at -20°C for up to 3 months. The end-user will need to be cautious about keeping the product at -20°C for long-term storage and determine the stability at such temperatures empirically as this is not tested internally.
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