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H5416

Sigma-Aldrich

FLT3 Ligand human

recombinant, expressed in HEK 293 cells, HumanKine®, suitable for cell culture

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About This Item

MDL-Nummer:
MFCD01634859
UNSPSC-Code:
12352202
NACRES:
NA.77

Biologische Quelle

human

Qualitätsniveau

100

Rekombinant

expressed in HEK 293 cells

Assay

≥95% (SDS-PAGE)

Form

lyophilized powder

Wirksamkeit

≤0.8 ng/mL EC50

Qualität

endotoxin tested

Mol-Gew.

monomer 24-30 kDa (glycosylated)

Verpackung

pkg of 10 μg

Lagerbedingungen

avoid repeated freeze/thaw cycles

Methode(n)

cell culture | mammalian: suitable

Verunreinigungen

≤1 EU/mg

Lagertemp.

−20°C

Verwandte Kategorien

Allgemeine Beschreibung

Human FMS-like tyrosine kinase 3 (FLT3) ligand is a homodimer consisting of two short-chain α-helical bundles. The molecular weight of FLT3 ligand is 44 kDa.

Biochem./physiol. Wirkung

FLT3 ligand binds to the cell-bound tyrosine kinase receptor and activates them.
HumanKine FLT3 Ligand is expressed in human HEK 293 cells as a glycosylated monomer with an apparent molecular mass of 24-30 kDa. HumanKine FLT3 Ligand in human HEK 293 cells contributes to glycosylation.FLT3 ligand is a hematopoietic cytokine that regulates the proliferation of early hematopoietic cells. It has been shown to synergize with a variety of cytokines to stimulate the growth and differentiation of early hematopoietic cells. The FLT3 ligand also stimulates the expansion of monocytes and immature dendritic cells, and induces early B cell lineage differentiation and NK cell growth.

Physikalische Form

Lyophilized from a 0.2 μm filtered solution of 1x PBS.

Hinweis zur Analyse

The specific activity was determined by the dose-dependent stimulation of the proliferation of the human acute myeloid leukemia cell line OCI-AML5.

Rechtliche Hinweise

HumanKine is a registered trademark of Proteintech Group, Inc. and Humanzyme, Inc

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

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Die Dokumentenbibliothek aufrufen

Flt3 ligand structure and unexpected commonalities of helical bundles and cystine knots
Savvides S N, et al.
Nature Structural and Molecular Biology, 7(6), 486-486 (2000)
Structure-function analysis of FLT3 ligand-FLT3 receptor interactions using a rapid functional screen
Graddis T, et al.
The Journal of Biological Chemistry, 273(28), 17626-17633 (1998)
Chunaram Choudhary et al.
International journal of hematology, 82(2), 93-99 (2005-09-09)
Activating mutations of Fms-like tyrosine kinase 3 (Flt3) are the most common genetic lesions in acute myeloid leukemia (AML) and are present in approximately one third of AML patients. The 2 classes of Flt3 mutations are internal tandem duplications in
Nobuyuki Onai et al.
Annals of the New York Academy of Sciences, 1106, 253-261 (2007-03-16)
Flt3-ligand is a nonredundant cytokine in type I interferon-producing cell (IPC) and dendritic cell (DC) development. We demonstrated that IPC and DC differentiation potential is confined to Flt3(+)-hematopoietic progenitor cells, that Flt3-ligand drives development along both lymphoid and myeloid developmental

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