G6416

GW5074

powder

• Synonym(e): 3-(3,5-Dibromo-4-hydroxybenzyliden)-5-iodo-1,3-dihydroindol-2-one
• Empirische Formel (Hill-System): C₁₅H₈Br₂INO₂
• CAS-Nummer: 220904-83-6
• Molekulargewicht: 520.94
• MDL-Nummer: MFCD03453076
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 24278455
• NACRES: NA.77

Eigenschaften

• Assay: ≥98% (HPLC)
• Form: powder
• Lagerbedingungen: protect from light
• Farbe: yellow to orange-brown
• Löslichkeit: DMSO: 5 mg/mL, clear
• Lagertemp.: room temp
• SMILES String: Oc1c(Br)cc(cc1Br)\C=C2/C(=O)Nc3ccc(I)cc23
• InChI: 1S/C15H8Br2INO2/c16-11-4-7(5-12(17)14(11)20)3-10-9-6-8(18)1-2-13(9)19-15(10)21/h1-6,20H,(H,19,21)/b10-3-
• InChIKey: LMXYVLFTZRPNRV-KMKOMSMNSA-N
• Angaben zum Gen: human ... RAF1(5894)

Beschreibung

Anwendung

GW5074 has been used as a specific inhibitor of cRaf1 in C2 murine skeletal myoblasts, HT-29 colorectal adenocarcinoma cell line and neutrophils.

Biochem./physiol. Wirkung

GW5074 is a cRaf1 kinase inhibitor, which is placed immediately downstream of Ras in the Motogen activated protein kinase (MAPK) signaling pathway. It elicits protection in GW5074 prevents degeneration in Huntington′s disease and also have therapeutic potential in treating neurodegenerative disorders. GW5074 in combination with anti-inflammatory drug, dexamethasone, attenuates sidestream smoke-induced airway inflammation.

Sonstige Hinweise

light sensitive

Rechtliche Hinweise

Sold for research purposes under agreement from Glaxo­Smith­Kline

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)