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G1921

Sigma-Aldrich

Glypican 3

recombinant, expressed in NSO cells

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About This Item

UNSPSC-Code:
12352202
NACRES:
NA.26

Biologische Quelle

human

Qualitätsniveau

200

Rekombinant

expressed in NSO cells

Assay

≥97% (SDS-PAGE)

Form

lyophilized powder

UniProt-Hinterlegungsnummer

P51654

Lagertemp.

−20°C

Angaben zum Gen

human ... GPC3(2719)

Allgemeine Beschreibung

Glypican-3, a cell surface protein, is highly expressed in hepatocellular carcinoma (HCC) and few other human cancers including melanoma. It is a heparan sulfate proteoglycan and is present on the cell surface. Under non-reducing conditions in SDS-PAGE, the glycanated glypican 3 appears as a smear with an apparent molecular mass of 60 - 100 kDa†

Biochem./physiol. Wirkung

Sulfate proteoglycan attached to the cell surface by a glycosylphosphatidylinositol (GPI) anchor. Regulates cell survival and inhibits cell proliferation during normal development. Potential use as marker for early disease detection.

Physikalische Form

Lyophilized from a 0.2 μm filtered solution in PBS containing 50 μg of bovine serum albumin per 1 μg of cytokine.

Lagerklassenschlüssel

13 - Non Combustible Solids

WGK

WGK 2

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

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Restriction enzyme cleavage of UV-irradiated DNA: a comparison of far-UV and mid-UV wavelengths.
S P Moore et al.
Photochemistry and photobiology, 45(2), 253-263 (1987-02-01)
Yu-Liang Wang et al.
World journal of gastroenterology, 18(19), 2408-2414 (2012-06-02)
To investigate the diagnostic value of glypican-3 (GPC3) and its relationship with hepatocellular carcinoma (HCC) recurrence after liver transplantation. HCC tissue samples (n = 31) obtained from patients who had undergone liver transplantation were analyzed. GPC3 mRNA and protein expression
Shiro Suzuki et al.
Human vaccines & immunotherapeutics, 10(2), 338-343 (2013-11-21)
Carcinoembryonic antigen glypican-3 (GPC3) is expressed by>40% of ovarian clear cell carcinoma (CCC) and is a promising immunotherapeutic target. We previously reported the safety of and immunological and clinical responses to a GPC3-derived peptide vaccine in a phase I clinical

Artikel

Glycosaminoglycan Sulfation and Signaling

Glycosaminoglycans are large linear polysaccharides constructed of repeating disaccharide units.

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