G1895

Gly-Pro-Arg-Pro

≥95% (HPLC)

• Synonym(e): GPRP, Glycyl-Prolyl-Arginyl-Proline amide
• Empirische Formel (Hill-System): C₁₈H₃₁N₇O₅
• CAS-Nummer: 67869-62-9
• Molekulargewicht: 425.48
• MDL-Nummer: MFCD00133378
• UNSPSC-Code: 12352209
• PubChem Substanz-ID: 24894914
• NACRES: NA.32

Eigenschaften

• Qualitätsniveau: 200
• Assay: ≥95% (HPLC)
• UniProt-Hinterlegungsnummer: P02751; P04937; P11276
• Lagertemp.: −20°C
• SMILES String: NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N2CCC[C@H]2C(O)=O
• InChI: 1S/C18H31N7O5/c19-10-14(26)24-8-2-5-12(24)15(27)23-11(4-1-7-22-18(20)21)16(28)25-9-3-6-13(25)17(29)30/h11-13H,1-10,19H2,(H,23,27)(H,29,30)(H4,20,21,22)/t11-,12-,13-/m0/s1
• InChIKey: WXPZDDCNKXMOMC-AVGNSLFASA-N
• Angaben zum Gen: human ... FN1(2335) ; mouse ... FN1(14268) ; rat ... FN1(25661)

Beschreibung

Amino Acid Sequence

Gly-Pro-Arg-Pro

Allgemeine Beschreibung

Gly-Pro-Arg-Pro is a peptide that mimics the N-terminal Gly-Pro-Arg region in the α chain of fibrin protein.[1]

Anwendung

Gly-Pro-Arg-Pro (GPRP) has been used for the formation of crystal composed of GPRP and the 30kDa C-terminal fragment from the γ chain of fibrinogen (rFbgγC30), cloned and expressed in Pichia pastoris.[1]

Biochem./physiol. Wirkung

Gly-Pro-Arg-Pro (GPRP) is capable of increasing free thrombin.[2] Thus it can be utilized to make thrombin-degranulated platelets, which helps in studying platelet reactions.[3]

Gly-Pro-Arg-Pro peptide suppresses the early steps of fibrin polymerization. The amide derivative of this peptide prevents the degradation of fibrinogen and fragment D by plasmin, even in the presence of EGTA (ethylene glycol-bis (β-aminoethyl ether)-N,N,N′,N′-tetraacetic acid).[4]

Inhibits fibrin polymerization.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)