F9505

Furazolidon

• Synonym(e): 3-(5-Nitrofurfurylidenamino)-2-oxazolidinon
• Empirische Formel (Hill-System): C₈H₇N₃O₅
• CAS-Nummer: 67-45-8
• Molekulargewicht: 225.16
• UNSPSC Code: 51102829
• NACRES: NA.85
• PubChem Substance ID: 24894997
• EC Number: 200-653-3
• Beilstein/REAXYS Number: 8317414
• MDL number: MFCD00010550

Eigenschaften

• biological source: synthetic
• Quality Segment: 200
• form: powder
• color: yellow
• mp: 256-256 °C
• solubility: formic acid: 50 mg/mL
• antibiotic activity spectrum: Gram-positive bacteria, parasites
• mode of action: enzyme | inhibits
• SMILES string: [O-][N+](=O)c1ccc(\C=N\N2CCOC2=O)o1
• InChI: 1S/C8H7N3O5/c12-8-10(3-4-15-8)9-5-6-1-2-7(16-6)11(13)14/h1-2,5H,3-4H2/b9-5+
• InChI key: PLHJDBGFXBMTGZ-WEVVVXLNSA-N

Beschreibung

Application

Furazolidone is a nitrofuran derivative with antiprotozoal and antibacterial activity. Furazolidone binds bacterial DNA, which leads to the gradual inhibition of monoamine oxidase. It is used to treat anorexia and antagonism of thiamin utilization in poultry[1]. Furazolidone increases thapsigargin-sensitive Ca²⁺-ATPase in chick cardiac myocytes.

Biochem/physiol Actions

Furazolidone and its generated free radicals, may bind to DNA and induce cross-links. Bacterial DNA is particularly susceptible to this drug, which results in high levels of mutations (transitions and transversions) in the bacterial chromosome. Its mechanism of action minimizes the development of resistant organisms. Furazolidone is a monoamine oxidase (MAO) inhibitor and is used as a DNA interstrand cross-linking agent.

Sicherheitshinweise

• pictograms: GHS08
• signalword: Warning
• hcodes: H361fd
• pcodes: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Hazard Classifications: Repr. 2
• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• ppe: Eyeshields, Gloves, type P3 (EN 143) respirator cartridges