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F9261

Sigma-Aldrich

Flunitrazepam

Synonym(e):

5-(2-Fluorphenyl)-1-methyl-7-nitro-3H-1,4-benzodiazepin-2(1H)-on, Ro 5-4200

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About This Item

Empirische Formel (Hill-System):
C16H12FN3O3
CAS-Nummer:
1622-62-4
Molekulargewicht:
313.28
EG-Nummer:
216-597-8
MDL-Nummer:
MFCD00057906
UNSPSC-Code:
12352200
PubChem Substanz-ID:
24894993
NACRES:
NA.77

Arzneimittelkontrolle

USDEA Schedule IV; Home Office Schedule 3; psychotrope (France); kontrollierte Droge in Deutschland; regulated under CDSA - not available from Sigma-Aldrich Canada; psicótropo (Spain); Decreto Lei 15/93: Tabela IIC (Portugal)

Löslichkeit

45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 1 mg/mL
DMF: soluble
ethanol: soluble

Ersteller

Roche

SMILES String

CN1C(=O)CN=C(c2ccccc2F)c3cc(ccc13)[N+]([O-])=O

InChI

1S/C16H12FN3O3/c1-19-14-7-6-10(20(22)23)8-12(14)16(18-9-15(19)21)11-4-2-3-5-13(11)17/h2-8H,9H2,1H3

InChIKey

PPTYJKAXVCCBDU-UHFFFAOYSA-N

Angaben zum Gen

human ... GABRA1(2554) , GABRA2(2555) , GABRA3(2556) , GABRA4(2557) , GABRA5(2558) , GABRA6(2559) , GABRB1(2560) , GABRB2(2561) , GABRB3(2562) , GABRD(2563) , GABRE(2564) , GABRG1(2565) , GABRG2(2566) , GABRG3(2567) , GABRP(2568) , GABRQ(55879)
rat ... Gabra2(29706)

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Biochem./physiol. Wirkung

Hypnotic; anxiolytic; ligand for the GABAA receptor benzodiazepine modulatory site.

Leistungsmerkmale und Vorteile

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the GABAA Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Piktogramme

Exclamation mark
GHS07

Signalwort

Warning

Gefahreneinstufungen

Acute Tox. 4 Oral - Aquatic Chronic 3 - STOT SE 3

Zielorgane

Central nervous system

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 2

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Analysenzertifikate (COA)

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R M McKernan et al.
Molecular pharmacology, 54(1), 33-43 (1998-07-11)
Photoincorporation of ligands into the benzodiazepine site of native gamma-aminobutyric acidA (GABAA) receptors provides useful information about the nature of the benzodiazepine (BZ) binding site. Photoincorporation of flunitrazepam into a single population of GABAA receptors, recombinant human alpha1beta3gamma2, was investigated
Danni Harris et al.
Journal of medicinal chemistry, 51(13), 3788-3803 (2008-06-10)
Ligands that bind to the benzodiazepine binding site on the GABA A receptor can attenuate or potentiate cognition. To investigate this property, the chemical determinants favoring selective binding or selective activation of the alpha5beta2gamma2 and alpha1beta2gamma2 GABA A receptor isoforms
M A Mattila et al.
Drugs, 20(5), 353-374 (1980-11-01)
Flunitrazepam is a benzodiazepine derivative whose hypnotic effect predominates over the sedative, anxiolytic, muscle-relaxing and anticonvulsant effects characteristic of benzodiazepines. Thus, it is used as a night-time hypnotic and in anaesthesiology: due to the pronounced hypnotic effect it is not
T Suzuki et al.
Endoscopy, 44(1), 38-42 (2011-12-07)
Studies have estimated that failure of cecal intubation occurs with conventional colonoscopy in up to 10 % of cases. Double-balloon endoscopy (DBE) systems, magnetic endoscope imaging (MEI), and transparent cap have been shown to improve success rates for colonoscopy. This study
Mari Takeuchi et al.
Annals of surgical oncology, 19(12), 3963-3970 (2012-06-16)
Postoperative delirium is a common complication after major surgery and is characterized by acute confusion with fluctuating consciousness. The aim of this study was to investigate the incidence and risk factors of postoperative delirium in patients with esophageal cancer. We
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