E-64c is a synthetic analog of E-64. E-64d is the ethyl ester of E-64c. E-64c is not cell permeable, but E-64d is cell permeable. E-64d is hydrolyzed in cell culture to E-64c.
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E8640
E-64d
powder, ≥98% (TLC)
Synonym(e):
(2S,3S)-trans-Epoxysuccinyl-L-leucylamido-3-methylbutan-ethylester, EST
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250 μG
139,00 €
1 MG
377,00 €
139,00 €
Versandbereit am10. April 2025Details
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250 μG
139,00 €
1 MG
377,00 €
About This Item
Empirische Formel (Hill-System):
C17H30N2O5
CAS-Nummer:
Molekulargewicht:
342.43
MDL-Nummer:
UNSPSC-Code:
12352202
PubChem Substanz-ID:
NACRES:
NA.77
139,00 €
Versandbereit am10. April 2025Details
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Produktbezeichnung
E-64d, protease inhibitor
Biologische Quelle
synthetic (organic)
Qualitätsniveau
Assay
≥98% (TLC)
Form
powder
Löslichkeit
methanol: water (1:1): 5 mg/mL, clear, colorless
Lagertemp.
−20°C
SMILES String
CCOC(=O)[C@H]1O[C@@H]1C(=O)N[C@@H](CC(C)C)C(=O)NCCC(C)C
InChI
1S/C17H30N2O5/c1-6-23-17(22)14-13(24-14)16(21)19-12(9-11(4)5)15(20)18-8-7-10(2)3/h10-14H,6-9H2,1-5H3,(H,18,20)(H,19,21)/t12-,13-,14-/m0/s1
InChIKey
SRVFFFJZQVENJC-IHRRRGAJSA-N
Angaben zum Gen
human ... CAPN1(823)
Anwendung
Biochem./physiol. Wirkung
E-64d ist ein Epoxysuccinyl-Peptid und ein Inhibitor von Cysteinprotease Cathepsin B[4] sowie Kalpain 1 und 2.[5] E-64d kann dank seiner die Protease Cathepsin B hemmenden Funktion potenziell als Arzneimittel für die Behandlung von Schädel-Hirn-Trauma (SHT)[5] und Alzheimer-Krankheit[6] dienen. Es hemmt das Oberflächenantigen von Gametozyten, was eine verringerte Produktion von Oozyten bei Plasmodium falciparum zur Folge hat.[7]
Lagerklassenschlüssel
11 - Combustible Solids
WGK
WGK 2
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
Persönliche Schutzausrüstung
dust mask type N95 (US), Eyeshields, Gloves
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Kunden haben sich ebenfalls angesehen
Inhibition of Plasmodium falciparum oocyst production by membrane-permeant cysteine protease inhibitor E64d
Eksi S, et al.
Antimicrobial Agents and Chemotherapy, 51(3), 1064-1070 (2007)
The cysteine protease inhibitor, E64d, reduces brain amyloid-beta and improves memory deficits in Alzheimer's disease animal models by inhibiting cathepsin B, but not BACE1, beta-secretase activity
Hook G, et al.
Journal of Alzheimer'S Disease, 26(2), 387-408 (2011)
Weidong Huang et al.
Scientific reports, 7(1), 13354-13354 (2017-10-19)
A cDNA library from a pool of all the seven silk glands from a tropical spider species was constructed. More than 1000 expressed sequence tag (EST) clones were created. Almost 65% of the EST clones were identified and around 50%
Ethambutol neutralizes lysosomes and causes lysosomal zinc accumulation
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Biochemical and Biophysical Research Communications, 471(1), 109-116 (2016)
John P Lloyd et al.
Scientific reports, 9(1), 12122-12122 (2019-08-23)
Extensive transcriptional activity occurring in intergenic regions of genomes has raised the question whether intergenic transcription represents the activity of novel genes or noisy expression. To address this, we evaluated cross-species and post-duplication sequence and expression conservation of intergenic transcribed
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What is the difference between E-64, E-64c and E-64d?
1 Antwort-
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What can I dissolve Product E8640, E-64d, in?
1 Antwort-
According to McGowan, E. B. et al., Biochem. Biophys. Res. Comm., 158(2), 432-435 (1989), this compound was dissolved in DMSO up to 200 mg/mL for use as an inhibitor of calpain in both intact and lysed platelets..
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Where can solutions of Product E8640, E-64d, be stored?
1 Antwort-
According to McGowan, E. B. et al., Biochem. Biophys. Res. Comm., 158(2), 432-435 (1989), solutions made in DMSO were stored at -70°C.
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What is the Department of Transportation shipping information for this product?
1 Antwort-
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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How does the storage temperature relate to shipping conditions?
1 Antwort-
The storage conditions that a Sigma-Aldrich catalog and label recommend for products are deliberately conservative. For many products, long-term storage at low temperatures will increase the time during which they are expected to remain in specification and therefore are labeled accordingly. Where short-term storage, shipping time frame, or exposure to conditions other than those recommended for long-term storage will not affect product quality, Sigma-Aldrich will ship at ambient temperature. The products sensitive to short-term exposure to conditions other than their recommended long-term storage are shipped on wet or dry ice. Ambient temperature shipping helps to control shipping costs for our customers. At any time, our customers can request wet- or dry-ice shipment, but the special handling is at customer expense if our product history indicates that the product is stable for regular shipment.
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