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E7881
Emodin
from Frangula bark, ≥90% (HPLC), casein Kinase 2 (CK2) inhibitor
Synonym(e):
1,3,8-Trihydroxy-6-methyl-9,10-anthracenedion, 1,3,8-Trihydroxy-6-methyl-anthrachinon, 6-Methyl-1,3,8-trihydroxy-anthrachinon, Archin, Emodol, Frangula-emodin, Frangulasäure, Rheum-Emodin
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50 MG
95,70 €
250 MG
339,00 €
About This Item
Empirische Formel (Hill-System):
C15H10O5
CAS-Nummer:
Molekulargewicht:
270.24
Beilstein:
1888141
EG-Nummer:
MDL-Nummer:
UNSPSC-Code:
12352200
PubChem Substanz-ID:
NACRES:
NA.77
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Produktbezeichnung
Emodin, from Frangula bark, ≥90% (HPLC)
Biologische Quelle
Frangula bark
Qualitätsniveau
Assay
≥90% (HPLC)
Löslichkeit
DMSO: soluble
aqueous base: soluble
ethanol: soluble
Lagertemp.
2-8°C
SMILES String
Cc1cc(O)c2C(=O)c3c(O)cc(O)cc3C(=O)c2c1
InChI
1S/C15H10O5/c1-6-2-8-12(10(17)3-6)15(20)13-9(14(8)19)4-7(16)5-11(13)18/h2-5,16-18H,1H3
InChIKey
RHMXXJGYXNZAPX-UHFFFAOYSA-N
Angaben zum Gen
human ... CSNK2A1(1457) , CSNK2B(1460) , ELA2(1991) , NFKB1(4790) , NKAP(79576) , NKRF(55922)
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Allgemeine Beschreibung
Emodin is an anthraquinone derivative, extracted from rhubarb (Rheum palmatum).[1] It has antibacterial,[1] anti-neoplastic, anti-inflammatory and anti-angiogenesis properties. Emodin exhibits cytotoxic effects, apoptosis and stimulates the expression of hypoxia-inducible factor 1α, glutathione S-transferase P and N-acetyltransferase.[2] It prevents the growth of prostate cancer cells.[1] Emodin is used to treat constipation and hemorrhoid. It displays immunosuppressive and anti-diabetic effects.[3]
Anwendung
Emodin has been used:
- to investigate its regulatory mechanisms on lipopolysaccharide (LPS)-induced inflammatory injury in myocarditis[4]
- as a reference standard for the development and validation of high performance liquid chromatography (HPLC)-photodiode array (PDA) assay method[3]
- to inhibit Tau aggregation[5]
- for direct binding assay[6]
Biochem./physiol. Wirkung
Inhibitor of NF-κB activation and adhesion molecule expression. Casein Kinase 2 (CK2) inhibitor.
Signalwort
Warning
H-Sätze
Gefahreneinstufungen
Acute Tox. 4 Oral
Lagerklassenschlüssel
11 - Combustible Solids
WGK
WGK 3
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
Persönliche Schutzausrüstung
dust mask type N95 (US), Eyeshields, Gloves
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Hajer Ouertatani-Sakouhi et al.
The Journal of biological chemistry, 285(34), 26581-26598 (2010-06-03)
Macrophage migration inhibitory factor (MIF), a proinflammatory cytokine, is considered an attractive therapeutic target in multiple inflammatory and autoimmune disorders. In addition to its known biologic activities, MIF can also function as a tautomerase. Several small molecules have been reported
Emodin and aloe-emodin suppress breast cancer cell proliferation through ERalpha inhibition
Huang PH, et al.
Evidence-Based Complementary and Alternative Medicine : ECAM, 2013 (2013)
Development and Validation of HPLC-PDA Assay method of Frangula emodin
Duca D and Farrugia C
Mediterranean Journal of Chemistry, 5(2), 374-386 (2016)
Michael Podvinec et al.
Journal of medicinal chemistry, 53(4), 1483-1495 (2010-01-30)
Dengue fever is a viral disease that affects 50-100 million people annually and is one of the most important emerging infectious diseases in many areas of the world. Currently, neither specific drugs nor vaccines are available. Here, we report on
Sheng-Zhang Lin et al.
PloS one, 7(8), e42146-e42146 (2012-08-10)
Emodin has been showed to induce apoptosis of pancreatic cancer cells and inhibit tumor growth in our previous studies. This study was designed to investigate whether emodin could inhibit the angiogenesis of pancreatic cancer tissues and its mechanism. In accordance
-
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