E1127

β-Estradiol 17-(β-D-glucuronide) sodium salt

• Synonym(e): 1,3,5(10)-Estratriene-3,17β-diol 17-glucuronide, 3,17β-Dihydroxy-1,3,5(10)-estratriene 17-glucuronide
• Lineare Formel: C₂₄H₃₁O₈Na
• CAS-Nummer: 15087-02-2
• Molekulargewicht: 470.49
• MDL-Nummer: MFCD00056557
• UNSPSC-Code: 51111800
• PubChem Substanz-ID: 24894388
• NACRES: NA.77

Eigenschaften

• Sterilität: non-sterile
• Assay: ≥98% (HPLC)
• Form: powder
• Löslichkeit: 0.1 M NaOH: 10 mg/mL, clear to slightly hazy, colorless to faintly yellow
• Versandbedingung: ambient
• Lagertemp.: −20°C
• SMILES String: [Na].CC12CCC3C(CCc4cc(O)ccc34)C1CCC2OC5OC(C(O)C(O)C5O)C(O)=O
• InChI: 1S/C24H32O8.Na.H/c1-24-9-8-14-13-5-3-12(25)10-11(13)2-4-15(14)16(24)6-7-17(24)31-23-20(28)18(26)19(27)21(32-23)22(29)30;;/h3,5,10,14-21,23,25-28H,2,4,6-9H2,1H3,(H,29,30);;
• InChIKey: GPLPNZUTAJWRLU-UHFFFAOYSA-N

Beschreibung

Anwendung

β-Estradiol 17-(β-D-glucuronide) sodium salt has been used as a standard to determine the quantity of β-Estradiol 17-(β-D-glucuronide) during UDP-glucuronosyltransferase assay.[1] It has also been used as a constituent of modified synthetic oviduct fluid (m-SOF) for maturation of bovine cumulus oocyte complexes (COC).[2][3]

Biochem./physiol. Wirkung

Estradiol 17-(β-D-glucuronide) (E217G) is a naturally occurring conjugated estrogen. It is formed in the liver and later excreted in bile. Increased concentrations of E217G leads to the development of cholestasis during the later stages of pregnancy, a condition which occurs with high frequency in the Dubin-Johnson syndrome.[4]

Leistungsmerkmale und Vorteile

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Sicherheitshinweise

• Piktogramme: GHS08,GHS07
• Signalwort: Warning
• H-Sätze: H302 + H312 + H332,H351
• P-Sätze: P202 - P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312 - P308 + P313
• Gefahreneinstufungen: Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Carc. 2
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type P3 (EN 143) respirator cartridges