D1944

D4476

≥98% (HPLC), solid

• Synonym(e): 4-(4-(2,3-Dihydrobenzo[1,4]dioxin-6-yl)-5-pyridin-2-yl-1H-imidazol-2-yl)benzamide
• Empirische Formel (Hill-System): C₂₃H₁₈N₄O₃
• CAS-Nummer: 301836-43-1
• Molekulargewicht: 398.41
• MDL-Nummer: MFCD28391149
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 329798715
• NACRES: NA.77

Eigenschaften

• Assay: ≥98% (HPLC)
• Form: solid
• Farbe: light yellow
• Löslichkeit: DMSO: ~20 mg/mL; H₂O: insoluble
• Ersteller: GlaxoSmithKline
• Lagertemp.: 2-8°C
• SMILES String: NC(=O)c1ccc(cc1)-c2nc(-c3ccccn3)c([nH]2)-c4ccc5OCCOc5c4
• InChI: 1S/C23H18N4O3/c24-22(28)14-4-6-15(7-5-14)23-26-20(21(27-23)17-3-1-2-10-25-17)16-8-9-18-19(13-16)30-12-11-29-18/h1-10,13H,11-12H2,(H2,24,28)(H,26,27)
• InChIKey: DPDZHVCKYBCJHW-UHFFFAOYSA-N

Beschreibung

Anwendung

D4476 has been used as a casein kinase I inhibitor (CKI) in various experiments.[1][2][3]

Biochem./physiol. Wirkung

D4476 is a potent, selective ATP-competitive inhibitor of CK1 (casein kinase 1).

D4476 may prevent or enhance apoptosis.[4] It triggers tumor suppressor p53 and impairs transcription factor E2F-1.[5]

Leistungsmerkmale und Vorteile

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)