D1068

DCB

≥98% (HPLC), solid

• Synonym(e): 3,3′-Dichlorobenzaldazine, NSC 67224
• Empirische Formel (Hill-System): C₁₄H₁₀Cl₂N₂
• CAS-Nummer: 6971-97-7
• Molekulargewicht: 277.15
• MDL-Nummer: MFCD00556081
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 24724458
• NACRES: NA.77

Eigenschaften

• Assay: ≥98% (HPLC)
• Form: solid
• Lagerbedingungen: desiccated; under inert gas
• Farbe: yellow
• Löslichkeit: DMSO: ~6.8 mg/mL; H₂O: insoluble
• Lagertemp.: 2-8°C
• SMILES String: Clc1cccc(\C=N\N=C\c2cccc(Cl)c2)c1
• InChI: 1S/C14H10Cl2N2/c15-13-5-1-3-11(7-13)9-17-18-10-12-4-2-6-14(16)8-12/h1-10H/b17-9+,18-10+
• InChIKey: XMOVWXSCYLINBJ-BEQMOXJMSA-N

Beschreibung

Biochem./physiol. Wirkung

3,3′-dichlorobenzaldazine (DCB) serves as an allosteric ligand with neutral cooperativity. It helps to block the positive allosteric regulation of mGluRs (metabotropic glutamate receptor subtype 5 (mGluR5) with the help of 3,3′-difluorobenzaldazine (DFB) and the negative modulatory effect of 3,3′-dimethoxybenzaldazine (DMeOB).[1]

Neutral allosteric modulator of the metabotropic glutamate receptor mGluR₅.

Leistungsmerkmale und Vorteile

This compound is featured on the Glutamate Receptors (G Protein Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Sicherheitshinweise

• Piktogramme: GHS05,GHS07,GHS09
• Signalwort: Danger
• H-Sätze: H302,H315,H317,H318,H335,H410
• P-Sätze: P261 - P273 - P280 - P301 + P312 - P302 + P352 - P305 + P351 + P338
• Gefahreneinstufungen: Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
• Zielorgane: Respiratory system
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Faceshields, Gloves