C7971

Cilostamide

phosphodiesterase inhibitor

• Synonym(e): 6-[3-(N-Cyclohexyl-N-methylcarbamoyl)propoxy]quinolin-2[1H]-one, OPC 3689
• Empirische Formel (Hill-System): C₂₀H₂₆N₂O₃
• CAS-Nummer: 68550-75-4
• Molekulargewicht: 342.43
• MDL-Nummer: MFCD00673958
• UNSPSC-Code: 12352202
• PubChem Substanz-ID: 24278337
• NACRES: NA.77

Eigenschaften

• Assay: ≥97% (HPLC)
• Form: powder
• Löslichkeit: DMSO: 20 mg/mL, clear, colorless to faintly yellow
• SMILES String: CN(C1CCCCC1)C(=O)CCCOc2ccc3NC(=O)C=Cc3c2
• InChI: 1S/C20H26N2O3/c1-22(16-6-3-2-4-7-16)20(24)8-5-13-25-17-10-11-18-15(14-17)9-12-19(23)21-18/h9-12,14,16H,2-8,13H2,1H3,(H,21,23)
• InChIKey: UIAYVIIHMORPSJ-UHFFFAOYSA-N
• Angaben zum Gen: human ... PDE3A(5139) , PDE3B(5140) , PDE5A(8654) , PDE7A(5150) ; rat ... Pde2a(81743) , Pde4a(25638)

Beschreibung

Biochem./physiol. Wirkung

PDE3 catalyzes the phosphodiester bond hydrolysis, observed in secondory messengers such as cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP). Inhibitors of PDE3 are generally inotropic and vasodilatory. They are being recognized for its use in treating heart failures.[1] Cilostamide is known to delay meiotic progression.[2]

Selective cGMP-inhibited phosphodiesterase inhibitor (PDE3); IC₅₀ = 70 ± 9 nM.

Selective inhibitor of PDE3 (cGMP-inhibited phosphodiesterase); IC₅₀ = 70 ± 9 nM. This inhibitory effect increases intracellular cAMP and inhibits platelet aggregation.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)