synthetic peptide corresponding to the first extracellular loop of human calcitonin receptor-like receptor, conjugated to KLH. The immunizing peptide has 100% homology with the rat and mouse gene.
Anwendung
Anti-Calcitonin Receptor-Like Receptor antibody produced in rabbit was used for immunocytochemistry of mouse bone marrow-derived mucosal mast cells at a dilution of 1:100.
Biochem./physiol. Wirkung
Calcitonin receptor-like receptor (CLR) is a G protein-coupled receptor that binds receptor-activity-modifying proteins (RAMP)1, -2 and -3. CLR has been implicated in conditions such as obesity, diabetes, osteoporosis, migraine and cardiovascular disease.
Physikalische Form
Solution in phosphate buffered saline containing ≤ 0.1% sodium azide.
Haftungsausschluss
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society, 23(2), e57-e68 (2010-10-23)
The parasitized or inflamed gastrointestinal mucosa shows an increase in the number of mucosal mast cells (MMC) and the density of extrinsic primary afferent nerve fibers containing the neuropeptide, calcitonin gene-related peptide (CGRP). Currently, the mode of action of CGRP
British journal of pharmacology, 166(1), 51-65 (2011-06-09)
The calcitonin receptor (CTR) and calcitonin receptor-like receptor (CLR) are two of the 15 human family B (or Secretin-like) GPCRs. CTR and CLR are of considerable biological interest as their pharmacology is moulded by interactions with receptor activity-modifying proteins. They
British journal of pharmacology, 166(1), 66-78 (2011-08-30)
The clinical effectiveness of antagonizing the calcitonin gene-related peptide (CGRP) receptor for relief of migraine pain has been clearly demonstrated, but the road to the development of these small molecule antagonists has been daunting. The key hurdle that needed to
Severe pain is a common and debilitating complication of metastatic bone cancer. Current analgesics provide insufficient pain relief and often lead to significant adverse effects. In models of cancer-induced bone pain, pathological sprouting of sensory fibers at the tumor-bone interface
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