C3042

Corticotropin-freisetzender Faktor, Mensch, Ratte

≥95% (HPLC), powder

• Synonym(e): CRF
• Empirische Formel (Hill-System): C₂₀₈H₃₄₄N₆₀O₆₃S₂
• CAS-Nummer: 86784-80-7
• Molekulargewicht: 4757.45
• MDL-Nummer: MFCD00213806
• UNSPSC-Code: 12352200
• NACRES: NA.32

Eigenschaften

• Biologische Quelle: human; rat
• Qualitätsniveau: 200
• Assay: ≥95% (HPLC)
• Form: powder
• Mol-Gew.: 4757.45
• Lagerbedingungen: (Keep container tightly closed in a dry and well-ventilated place)
• Methode(n): activity assay: suitable
• Löslichkeit: water: 1.00-1.04 mg/mL, colorless
• UniProt-Hinterlegungsnummer: P06850
• Lagertemp.: −20°C
• InChIKey: VXFVFWFSJFSXHN-FAUHKOHMSA-N
• Angaben zum Gen: human ... CRH(1392)

Beschreibung

Amino Acid Sequence

Ser-Glu-Glu-Pro-Pro-Ile-Ser-Leu-Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-Glu-Val-Leu-Glu-Met-Ala-Arg-Ala-Glu-Gln-Leu-Ala-Gln-Gln-Ala-His-Ser-Asn-Arg-Lys-Leu-Met-Glu-Ile-Ile-NH2

Allgemeine Beschreibung

The corticotropin-releasing factor is a 41-amino-acid polypeptide.[1] It is expressed in neurons, the hypothalamus, and the amygdala.[2]

Research area: Neuroscience

Anwendung

Corticotropin Releasing Factor human, rat has been used:

• as a component in Dulbecco′s modified eagle medium (DMEM) for incubating lung explants[3]
• as a component in serum-free complete medium for isolation and culturing of fetal distal lung epithelial cells[4]
• in the synthesis of the corticotropin-releasing factor(CRF)-TAMRA 1 mixture[5]
• in chronic intracerebroventicular administration, to study its effect on hypoxia in hippocampus[6]

Biochem./physiol. Wirkung

CRF is a hypothalamic peptide that releases ACTH and endorphin from the anterior pituitary. It is also a neurotransmitter in the central nervous system, and is involved in autonomic and endocrine responses to stress.

Corticotropin-releasing factor modulates stress responses.[7][1] It facilitates stress-stimulated activation of the hypothalamic−pituitary−adrenal system.[8]Corticotropin Releasing Factor/hormone (CRF/H) at higher levels has been observed in stress-related physiological and behavioral disorders. It has been involved in anxiety and depression disorders.[9] Under stress conditions, the release of CRH activates the corticotrophin-releasing hormone receptor type I (CRHR1) in the anterior pituitary for the release of adrenocorticotropic hormone (ACTH) that further stimulates the production/secretion of cortisol/corticosterone.[10]

Releases ACTH and endorphin from the anterior pituitary; central nervous system neurotransmitter.

Sonstige Hinweise

Lyophilized from 0.1% TFA in H2O

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)