C1494

Carmofur

≥98% (HPLC), powder

• Synonym(e): 1-Hexylcarbamoyl-5-fluorouracil, HCFU
• Empirische Formel (Hill-System): C₁₁H₁₆FN₃O₃
• CAS-Nummer: 61422-45-5
• Molekulargewicht: 257.26
• MDL-Nummer: MFCD00866284
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 329774890
• NACRES: NA.77

Eigenschaften

• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: white to off-white
• Löslichkeit: DMSO: >15 mg/mL
• Lagertemp.: 2-8°C
• SMILES String: CCCCCCNC(=O)N1C=C(F)C(=O)NC1=O
• InChI: 1S/C11H16FN3O3/c1-2-3-4-5-6-13-10(17)15-7-8(12)9(16)14-11(15)18/h7H,2-6H2,1H3,(H,13,17)(H,14,16,18)
• InChIKey: AOCCBINRVIKJHY-UHFFFAOYSA-N

Beschreibung

Anwendung

Carmofur has been used as an inhibitor of acid ceramidase to study its effects on glucosylsphingosine (GlcSph) production in human embryonic kidney 293T (HEK293T) cells. It has also been used as an inhibitor of acid ceramidase to study its effects on acid‐mediated hydrolysis of ceramide which kicks-in consumption and the generation of sphingosine .

Biochem./physiol. Wirkung

Carmofur acts as an inhibitor of fatty acid amide hydrolase (FAAH), N-acylethanolamine acid amidase (NAAA) and acid ceramidase (ASAH1). Carmofur has a therapeutic activity against colorectal and cervical cancer. It can inhibit the severe acute respiratory syndrome (SARS)-CoV-2 main protease (M^pro) in vitro.

Carmofur is a derivative of fluorouracil, an antimetabolite used as an antineoplastic agent.

Sicherheitshinweise

• Piktogramme: GHS06,GHS08
• Signalwort: Danger
• H-Sätze: H301,H361
• P-Sätze: P201 - P301 + P310 + P330
• Gefahreneinstufungen: Acute Tox. 3 Oral - Repr. 2
• Lagerklassenschlüssel: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable