B6060

BVT.948

≥98% (HPLC), solid

• Synonym(e): 4-Hydroxy-3,3-dimethyl-2H-benzo[g]indole-2,5(3H)-dione
• Empirische Formel (Hill-System): C₁₄H₁₁NO₃
• CAS-Nummer: 39674-97-0
• Molekulargewicht: 241.24
• NACRES: NA.77
• PubChem Substance ID: 24724422
• UNSPSC Code: 12352200
• MDL number: MFCD00616487
• Assay: ≥98% (HPLC)
• Form: solid
• Quality level: 100
• Storage condition: desiccated, protect from light, under inert gas

Eigenschaften

• Quality Level: 100
• assay: ≥98% (HPLC)
• form: solid
• storage condition: desiccated, protect from light, under inert gas
• color: red
• solubility: DMSO: 18 mg/mL, H₂O: insoluble
• storage temp.: −20°C
• SMILES string: CC1(C)C(=O)N=C2c3ccccc3C(=O)C(O)=C12
• InChI: 1S/C14H11NO3/c1-14(2)9-10(15-13(14)18)7-5-3-4-6-8(7)11(16)12(9)17/h3-6,17H,1-2H3
• InChI key: BAQXWJQSUXZVIP-UHFFFAOYSA-N

Beschreibung

Biochem/physiol Actions

BVT.948 is a non-competitive inhibitor of protein tyrosine phosphatase (PTP). Enhances insulin signaling in cells and inhibits several cytochrome P450 isoforms in vitro.

Features and Benefits

BVT.948 is a non-competitive inhibitor of protein tyrosine phosphatase (PTP). Enhances insulin signaling in cells and inhibits several cytochrome P450 isoforms in vitro. Works through a different mechanism then the other PTP inhibitors. BVT.948 was able to enhance insulin signaling in cells, although it did not increase tyrosine phosphorylation globally. Furthermore, the compound was active in vivo, enhancing insulin tolerance tests in ob/ob mice, therefore apparently enhancing insulin sensitivity. BVT.948 was able to inhibit several other PTPs tested and also was efficient at inhibiting several cytochrome P450 isoforms in vitro.

Sicherheitshinweise

• pictograms: GHS07
• signalword: Warning
• hcodes: H317
• pcodes: P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364
• Hazard Classifications: Skin Sens. 1
• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Faceshields, Gloves