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A5626

Sigma-Aldrich

Acetylthiocholinchlorid

≥99% (TLC), powder

Synonym(e):

(2-Mercaptoethyl)trimethylammonium chloride acetate

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About This Item

Lineare Formel:
CH3COSCH2CH2N(CH3)3Cl
CAS-Nummer:
6050-81-3
Molekulargewicht:
197.73
EG-Nummer:
227-953-7
MDL-Nummer:
MFCD00038727
UNSPSC-Code:
12352204
PubChem Substanz-ID:
24278219
NACRES:
NA.83

Assay

≥99% (TLC)

Form

powder

Löslichkeit

water: 100 mg/mL, clear to slightly hazy, colorless

Lagertemp.

−20°C

SMILES String

[Cl-].CC(=O)SCC[N+](C)(C)C

InChI

1S/C7H16NOS.ClH/c1-7(9)10-6-5-8(2,3)4;/h5-6H2,1-4H3;1H/q+1;/p-1

InChIKey

GZYVLKKMMDFCKR-UHFFFAOYSA-M

Angaben zum Gen

human ... ACHE(43)

Anwendung

Acetylthiocholine chloride has been used to determine the acetylcholine esterase activity of semen exosomes (SE). It has also been used as a substrate for acetylcholine esterase in microcalorimetric study of its kinetic parameters.

Biochem./physiol. Wirkung

Acetylcholinesterase (AChE) enzyme plays an important physiological role in the neurotransmission process.
Acetylcholinesterase-Substrat und Agonist für nikotinische Acetylcholinrezeptoren.

Piktogramme

Corrosion
GHS05

Signalwort

Danger

H-Sätze

H318

Gefahreneinstufungen

Eye Dam. 1

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

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Die Dokumentenbibliothek aufrufen

Tanja Botić et al.
European journal of medicinal chemistry, 136, 294-304 (2017-05-16)
The brominated pyrroloiminoquinone alkaloids discorhabdins B, L and G and 3-dihydro-7,8- dehydrodiscorhabdin C, isolated from methanol extracts of two specimens of Latrunculia sp. sponges collected near the Antarctic Peninsula, are here demonstrated for the first time to be reversible competitive
Isolation of Exosomes from Semen for in vitro Uptake and HIV-1 Infection Assays
Madison MN, et al.
Bio-protocol, 7(7) (2017)
Lindon W K Moodie et al.
Organic & biomolecular chemistry, 14(47), 11220-11229 (2016-11-15)
The marine secondary metabolite stryphnusin (1) was isolated from the boreal sponge Stryphnus fortis, collected off the Norwegian coast. Given its resemblance to other natural acetylcholinesterase antagonists, it was evaluated against electric eel acetylcholinesterase and displayed inhibitory activity. A library
Konstantin A Petrov et al.
Scientific reports, 8(1), 304-304 (2018-01-13)
Non-selective inhibitors of cholinesterases (ChEs) are clinically used for treatment of myasthenia gravis (MG). While being generally safe, they cause numerous adverse effects including induction of hyperactivity of urinary bladder and intestines affecting quality of patients life. In this study
Jerneja Kladnik et al.
International journal of molecular sciences, 21(16) (2020-08-13)
The increasing number of Alzheimer's disease (AD) cases requires the development of new improved drug candidates, possessing the ability of more efficient treatment as well as less unwanted side effects. Cholinesterase enzymes are highly associated with the development of AD
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