A270
Anti-α1 Adrenergic Receptor antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
Synonym(e):
Anti-ADRA1, Anti-ALPHA1BAR
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About This Item
Empfohlene Produkte
Biologische Quelle
rabbit
Qualitätsniveau
Konjugat
unconjugated
Antikörperform
affinity isolated antibody
Antikörper-Produkttyp
primary antibodies
Klon
polyclonal
Form
buffered aqueous solution
Mol-Gew.
antigen ~60 kDa
Speziesreaktivität
mouse, human, rat
Methode(n)
indirect immunofluorescence: 1:1,000 using mouse kidney distal tubule cells
western blot: 1:400
UniProt-Hinterlegungsnummer
Versandbedingung
dry ice
Lagertemp.
−20°C
Posttranslationale Modifikation Target
unmodified
Angaben zum Gen
human ... ADRA1A(148) , ADRA1B(147) , ADRA1D(146)
mouse ... Adra1d(11550)
rat ... Adra1d(29413)
Allgemeine Beschreibung
Adrenergic receptors (ARs) are members of the 7-transmembrane domain G protein-coupled receptor superfamily that bind the endogenous catecholamines epinephrine and norepinephrine. Pharmacological, structural, and molecular cloning data indicate significant heterogeneity within this receptor family. Nine receptor subtypes have been identified thus far including three α1AR subtypes (α1A/D, α1B, and α1C), three α2ARs (α2A, α2B, and α2C), and three βAR subtypes (β1, β2, and β3). Adrenergic receptors participate in either the onset or maintenance of several disease states including hypertension, cardiac dysfunction (congestive heart failure, ischemia, arrhythmias), diabetes, glaucoma, depression, and impotence.
Adrenergic receptors are a G-protien coupled receptors that exist in two forms, α or β. Ligands for adrenergic receptors are catecholamines that induce a sympathetic response in animal cells.
Rabbit polyclonal Anti-α1 Adrenergic Receptor antibody is human α1 adrenergic receptor subtype-specific and cross-reacts with rat and mouse α1 adrenergic receptor in immunoblotting. It detects α1 adrenergic receptor in mouse kidney membrane preparations by immunoblotting and stains plasma membrane of mouse kidney distal tubule cells in immunofluorescence.
Immunogen
A270 is produced by immunizing New Zealand white rabbits with a synthetic peptide corresponding to aa residues 339-349 of human alpha 1a adrenergic receptor. This sequence is 100% conserved within the 3rd intracellular loop of all alpha1 adrenergic receptors. Peptide sequence: K339-F-S-R-E-K-K-A-A-K-T349
Anwendung
Rabbit polyclonal Anti-α1 Adrenergic Receptor antibody is used for the localization and detection of the α1 adrenergic receptor (~ 60 kDa). It can be used in immunoblotting and immunofluorescence techniques.
Physikalische Form
Solution in phosphate buffered saline containing 1 mg/ml BSA and 0.05% sodium azide.
Haftungsausschluss
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Lagerklassenschlüssel
10 - Combustible liquids
WGK
WGK 1
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
Persönliche Schutzausrüstung
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
Analysenzertifikate (COA)
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Julien Roche et al.
Sub-cellular biochemistry, 72, 261-278 (2015-07-16)
Defining the physical-chemical determinants of protein folding and stability, under normal and pathological conditions has constituted a major subfield in biophysical chemistry for over 50 years. Although a great deal of progress has been made in recent years towards this
X D Tang et al.
The Journal of general physiology, 117(3), 253-274 (2001-02-27)
Reactive oxygen/nitrogen species are readily generated in vivo, playing roles in many physiological and pathological conditions, such as Alzheimer's disease and Parkinson's disease, by oxidatively modifying various proteins. Previous studies indicate that large conductance Ca(2+)-activated K(+) channels (BK(Ca) or Slo)
E S Drummond et al.
Neuroscience, 281, 99-109 (2014-10-01)
In certain forms of nerve injury and inflammation, noradrenaline augments pain via actions on up-regulated α1-adrenoceptors (α1-ARs). The aim of this study was to use immunohistochemistry to examine α1-AR expression on peripheral neurons, cutaneous blood vessels and keratinocytes after distal
Peter D Drummond et al.
Pain, 155(3), 606-616 (2013-12-18)
After peripheral nerve injury, nociceptive afferents acquire an abnormal excitability to adrenergic agents, possibly due to an enhanced expression of α1-adrenoceptors (α1-ARs) on these nerve fibres. To investigate this in the present study, changes in α1-AR expression on nerve fibres
Mária Dux et al.
European journal of pain (London, England), 24(2), 383-397 (2019-10-30)
The α1 -adrenoceptor agonist, phenylephrine, is used at high concentrations as a mydriatic agent and for the treatment of nasal congestion. Among its adverse side-effects transient burning sensations are reported indicating activation of the trigeminal nociceptive system. Neuropeptide release, calcium
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