B9031

(−)-Bilobalide from Ginkgo biloba leaves

≥93% (HPLC)

• Synonym(e): Bilobalide
• Empirische Formel (Hill-System): C₁₅H₁₈O₈
• CAS-Nummer: 33570-04-6
• Molekulargewicht: 326.30
• MDL-Nummer: MFCD00238547
• UNSPSC-Code: 85151701
• PubChem Substanz-ID: 24892116
• NACRES: NA.28

Eigenschaften

• Biologische Quelle: plant leaves (Ginkgo biloba)
• Assay: ≥93% (HPLC)
• Form: powder
• Methode(n): HPLC: suitable
• Farbe: white
• Lagertemp.: −20°C
• SMILES String: CC(C)(C)[C@]1(O)CC2OC(=O)C[C@@]23C(=O)OC4OC(=O)[C@H](O)[C@]134
• InChI: 1S/C15H18O8/c1-12(2,3)14(20)4-6-13(5-7(16)21-6)10(19)23-11-15(13,14)8(17)9(18)22-11/h6,8,11,17,20H,4-5H2,1-3H3/t6-,8-,11-,13-,14+,15+/m0/s1
• InChIKey: MOLPUWBMSBJXER-YDGSQGCISA-N

Beschreibung

Allgemeine Beschreibung

Bilobalide is a biologically active terpenic trilactone (terpenoid) extracted from Ginkgo biloba. It is synthesized from geranylgeranyl pyrophosphate (GGPP).

Anwendung

(-)-Bilobalide from Ginkgo biloba leaves has been used as a reference substance to study the antimicrobial activity of different fractions of G.biloba leaves against a number of Gram-positive and negative bacteria and yeasts.

Biochem./physiol. Wirkung

Bilobalide is an inducer of cytochrome P450 enzymes CYP3A1 and CYP1A2. It exhibits neuroprotective, anti-inflammatory, anti-oxidative and anti-apoptotic properties. Bilobalide, a γ-aminobutyric acid (GABA) A_A-rho, 5-hydroxytryptamine type 3 (5-HT(3)) receptor antagonist, may be used to study the function of these receptors in the brain processes such as cognition and memory. It serves as a specific platelet-activating factor receptor antagonist, which helps in the treatment of cardiovascular (Alzheimer′s disease) and cerebrovascular diseases.

Bioactive terpenoid found in Ginkgo biloba.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)