A1755

Aminophyllin

≥98%, powder

• Synonym(e): (Theophyllin)₂ · Ethylendiamin, 3,7-Dihydro-1,3-dimethyl-1H-purin-2,6-dion, komplexiert mit 1,2-Ethandiamin (2:1), Theophyllin-Hemiethylendiaminkomplex
• Empirische Formel (Hill-System): C₇H₈N₄O₂ · 0.5C₂H₈N₂
• CAS-Nummer: 317-34-0
• Molekulargewicht: 210.21
• EG-Nummer: 206-264-5
• MDL-Nummer: MFCD00013221
• UNSPSC-Code: 41106305
• PubChem Substanz-ID: 24277691
• NACRES: NA.77

Eigenschaften

• Assay: ≥98%
• Form: powder
• Farbe: white to off-white
• Löslichkeit: H₂O: 50 mg/mL (solutions should be freshly prepared.); alcohol: insoluble
• Lagertemp.: −20°C
• SMILES String: NCCN.CN1C(=O)N(C)c2nc[nH]c2C1=O.CN3C(=O)N(C)c4nc[nH]c4C3=O
• InChI: 1S/2C7H8N4O2.C2H8N2/c2*1-10-5-4(8-3-9-5)6(12)11(2)7(10)13;3-1-2-4/h2*3H,1-2H3,(H,8,9);1-4H2
• InChIKey: FQPFAHBPWDRTLU-UHFFFAOYSA-N
• Angaben zum Gen: human ... ADORA1(134) , ADORA2A(135) , ADORA2B(136) , ADORA3(140) , PDE3A(5139) , PDE3B(5140) , PDE4A(5141) , PDE4B(5142) , PDE4C(5143) , PDE4D(5144)

Beschreibung

Anwendung

Aminophylline has been used:

• as a positive control in the selective inhibitor of nuclear export, KPT-350 zebrafish dosing experiments[1]
• as a positive control for the determination of the spasmolytic activity of C. aeruginosa extracts[2]
• as a phosphodiesterase (PDE) inhibitor in inhibitor studies to quantify its potency to inhibit PDE4A1A and PDE3A enzyme in an assay[3]

Biochem./physiol. Wirkung

Non-selective phosphodiesterase (PDE) inhibitor. Antiepileptic drug

Aminophylline is a methylxanthine compound containing theophylline andethylenediamine in a ratio of 2:1. It acts as a bronchodilator and is used to treat chronic lung diseases like asthma, bronchitis, or emphysema.[4]

Sicherheitshinweise

• Piktogramme: GHS06
• Signalwort: Danger
• H-Sätze: H301
• P-Sätze: P264 - P270 - P301 + P310 - P405 - P501
• Gefahreneinstufungen: Acute Tox. 3 Oral
• Lagerklassenschlüssel: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Faceshields, Gloves