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59815

Sigma-Aldrich

1-(4-Isothiocyanatobenzyl)-ethylendiamin-N,N,N′,N′-tetraessigsäure

~90% (HPLC)

Synonym(e):

Isothiocyanatobenzyl-EDTA

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About This Item

Empirische Formel (Hill-System):
C18H21N3O8S
CAS-Nummer:
105394-74-9
Molekulargewicht:
439.44
Beilstein:
8363400
MDL-Nummer:
MFCD00236411
UNSPSC-Code:
12352106
PubChem Substanz-ID:
57651699
NACRES:
NA.25

Assay

~90% (HPLC)

Versandbedingung

wet ice

Lagertemp.

−20°C

SMILES String

OC(=O)CN(CC(Cc1ccc(cc1)N=C=S)N(CC(O)=O)CC(O)=O)CC(O)=O

InChI

1S/C18H21N3O8S/c22-15(23)7-20(8-16(24)25)6-14(21(9-17(26)27)10-18(28)29)5-12-1-3-13(4-2-12)19-11-30/h1-4,14H,5-10H2,(H,22,23)(H,24,25)(H,26,27)(H,28,29)

InChIKey

VHMWJVAFPCGUTJ-UHFFFAOYSA-N

Anwendung

Isothiocyanatobenzyl-EDTA is a bifunctional chelator used in bioconjugation chemistry to label primary amine containing molecules and proteins preferentially at their N-terminals.

Sonstige Hinweise

Amine-reactive probe, useful for antibody chelate labelling

Piktogramme

Exclamation mark
GHS07

Signalwort

Warning

Gefahreneinstufungen

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Zielorgane

Respiratory system

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

dust mask type N95 (US), Eyeshields, Gloves

Analysenzertifikate (COA)

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T M Rana et al.
Bioconjugate chemistry, 1(5), 357-362 (1990-09-01)
Conjugates of monoclonal antibodies with drugs, toxins, radionuclides, and other agents are in widespread use in therapeutic trials and as clinical research tools. The characterization of these immunoconjugates generally does not include determining the individual sites at which such agents
S V Deshpande et al.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 31(2), 218-224 (1990-02-01)
The metabolism of radiolabeled antibodies is important for radioimmunoimaging and therapy. The loss of indium-111 (111In) from the chelate can pose problems in imaging and increases the radiation dose to normal tissues. We have evaluated the loss in vivo of
K Shah et al.
Bioconjugate chemistry, 7(3), 283-289 (1996-05-01)
The synthesis of a C-5 modified uridine phosphoramidite which contains a primary amino group protected with Fmoc is described. During cleavage and deprotection of chemically synthesized RNA, the Fmoc protecting group is removed to yield a free amino group at
Z Yao et al.
Nuclear medicine and biology, 22(2), 199-203 (1995-02-01)
Tn antigen is a glycosylated tumor associated antigen and a murine monoclonal antibody, MLS128, has been identified to react with it. The potential of MLS128 for the radioimmunoimaging of colorectal cancer was studied. MLS128 was labeled with radioiodine by the

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