The stability of this product in solution is not determined. However, similar product F3506 states that solutions of N-Formyl-Met-Leu-Phe can be stored, in aliquots, at -20°C for at least six months.
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47729
N-Formyl-Met-Leu-Phe
≥99.0% (TLC), BioXtra
Synonym(e):
Chemotaktisches Peptid, N-Formyl-L-methionyl-L-leucyl-L-phenylalanin, fMLP (misnomer but widely used)
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10 MG
116,00 €
About This Item
Empirische Formel (Hill-System):
C21H31N3O5S
CAS-Nummer:
Molekulargewicht:
437.55
Beilstein:
2315783
MDL-Nummer:
UNSPSC-Code:
12352209
PubChem Substanz-ID:
NACRES:
NA.26
Empfohlene Produkte
Produktbezeichnung
N-Formyl-Met-Leu-Phe, BioXtra, ≥99.0% (TLC)
Produktlinie
BioXtra
Qualitätsniveau
Assay
≥99.0% (TLC)
Form
powder
Farbe
white
Löslichkeit
DMF: 50 mg/mL, clear, colorless
Anwendung(en)
cell analysis
Lagertemp.
2-8°C
SMILES String
CSCC[C@H](NC=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(O)=O
InChI
1S/C21H31N3O5S/c1-14(2)11-17(23-19(26)16(22-13-25)9-10-30-3)20(27)24-18(21(28)29)12-15-7-5-4-6-8-15/h4-8,13-14,16-18H,9-12H2,1-3H3,(H,22,25)(H,23,26)(H,24,27)(H,28,29)/t16-,17-,18-/m0/s1
InChIKey
PRQROPMIIGLWRP-BZSNNMDCSA-N
Angaben zum Gen
human ... FPR1(2357)
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Amino Acid Sequence
NFor-Met-Leu-Phe
Anwendung
1. 4th and 5th applications do not have access
2. 3rd application is not relevant
2. 3rd application is not relevant
Biochem./physiol. Wirkung
Potentes chemotaktisches Peptid. Induziert einen metabolischen Burst in Makrophagen, zusammen mit einer Steigerung der Atemfrequenz, Sekretion von lysosomalen Enzymen und Produktion von Superoxidanion.
N-Formyl-Met-Leu-Phe is a potent chemotactic peptide and formyl peptide receptor (FPR) agonist that induces a metabolic burst in macrophages accompanied by an increase in respiratory rate, secretion of lysosomal enzymes, and production of superoxide anion.
Verpackung
Bottomless glass bottle. Contents are inside inserted fused cone.
Lagerklassenschlüssel
11 - Combustible Solids
WGK
WGK 3
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
Persönliche Schutzausrüstung
Eyeshields, Gloves, type N95 (US)
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C Dahlgren et al.
Blood, 95(5), 1810-1818 (2000-02-26)
A D-methionine-containing peptide, Trp-Lys-Tyr-Met-Val-D-Met-NH(2) (WKYMVm), featuring a unique receptor specificity was investigated with respect to its ability to activate neutrophil effector functions. The peptide was found to be more potent than the N-formylated peptide N-formyl-Met-Leu-Phe (fMLF) at inducing neutrophil chemotaxis
Astrid L Voskamp et al.
The journal of allergy and clinical immunology. In practice, 3(2), 192-199 (2015-02-03)
Allergic bronchopulmonary aspergillosis (ABPA) often presents with persistently uncontrolled asthma despite the use of corticosteroids and antifungal therapy. Omalizumab is a humanized anti-IgE monoclonal antibody currently used to treat severe asthma. The aim was to assess the clinical and immunologic
Alexandra F Santos et al.
The Journal of allergy and clinical immunology, 134(3), 645-652 (2014-07-30)
Most of the peanut-sensitized children do not have clinical peanut allergy. In equivocal cases, oral food challenges (OFCs) are required. However, OFCs are laborious and not without risk; thus, a test that could accurately diagnose peanut allergy and reduce the
Off-pump coronary artery bypass surgery induces prolonged alterations to host neutrophil physiology.
J James B Edelman et al.
Shock (Augusta, Ga.), 39(2), 149-154 (2013-01-18)
Persistent alteration to host polymorphonuclear cell (PMN) physiology has been demonstrated after cardiac surgery performed with cardiopulmonary bypass (CPB). However, to date, PMN physiology and function beyond the first 24 h have not been investigated after cardiac surgery performed without
Karama Makni-Maalej et al.
Journal of immunology (Baltimore, Md. : 1950), 189(9), 4657-4665 (2012-09-25)
Superoxide anion production by the neutrophil NADPH oxidase plays a key role in host defense; however, excessive superoxide production is believed to participate to inflammatory reactions. Neutrophils express several TLR that recognize a variety of microbial motifs or agonists. The
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How long can this product be stored at -20 when reconstituted in DMSO?
1 Antwort-
Hilfreich?
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What is the solubility of the product 47729, N-Formyl-Met-Leu-Phe?
1 Antwort-
Product is soluble in water (partly), methanol, DMSO (4 mg/ml), ethanol (2 mg/ml), and DMF (Dimethylformamide) (50 mg/ml).
Hilfreich?
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Can this product be dissolved in DMSO?
1 Antwort-
Yes, this product can be solubilized in DMSO. The exact concentration at which it may be solubilized is not determined. However, several sources state that it is soluble in DMSO at 30 mg/mL.
Hilfreich?
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