424M-1

CITED1 (5H6) Mouse Monoclonal Antibody

• UNSPSC-Code: 12352203
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: mouse
• Qualitätsniveau: 100; 500
• Konjugat: unconjugated
• Antikörperform: ascites fluid
• Antikörper-Produkttyp: primary antibodies
• Klon: 5H6, monoclonal
• Beschreibung: (For In Vitro Diagnostic Use in Select Regions (See Chart))
• Form: buffered aqueous solution
• Speziesreaktivität: human
• Verpackung: vial of 0.1 mL concentrate (424M-14); vial of 0.5 mL concentrate (424M-15); bottle of 1.0 mL predilute (424M-17); vial of 1.0 mL concentrate (424M-16); bottle of 7.0 mL predilute (424M-18)
• Hersteller/Markenname: Cell Marque^®
• Methode(n): immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100
• Isotyp: IgG2aκ
• Kontrolle: Wilms’ tumor
• Versandbedingung: wet ice
• Lagertemp.: 2-8°C
• Visualisierung: nuclear
• Angaben zum Gen: human ... CITED1(4435)

Beschreibung

Allgemeine Beschreibung

CITED1 is a transcriptional cofactor expressed in the metanephric mesenchyme (MM) of the embryonic kidney and is down-regulated as these cells undergo epithelial differentiation.^1-4 It is thought that CITED1 may play a role in maintaining MM cells in an undifferentiated state.³ Wilms′ tumors (WT) are thought to arise from abnormal postnatal retention and dysregulated differentiation of nephrogenic progenitor cells that originate as a condensed MM within embryonic kidneys.¹ CITED1 expression has been shown to persist in blastemal cell populations of human WT.^1,2 In the developing embryonic kidney, CITED1 expression is seen in the cytoplasmic compartment. In WT, expression of CITED1 is detected in the nuclear compartment of tumor cells.^1-4 It has been suggested that persistent expression of CITED1 in the MM could play a role in WT initiation and pathogenesis.¹ CITED1 has been detected in 86.8% of WT Cases.²

Qualität

IVD

IVD

IVD

RUO

Verlinkung

CITED1 Positive Control Slides, Product No. 424S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Physikalische Form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

Angaben zur Herstellung

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Sonstige Hinweise

For Technical Service please contact: 800-665-7284 or email: [email protected]

Rechtliche Hinweise

Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany