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Sigma-Aldrich

N-Butyryl-DL-homocystein-thiolacton

≥97.0% (HPLC)

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About This Item

Empirische Formel (Hill-System):
C8H13NO2S
CAS-Nummer:
39837-08-6
Molekulargewicht:
187.26
MDL-Nummer:
MFCD01862916
UNSPSC-Code:
12352200
eCl@ss:
32160406
PubChem Substanz-ID:
57646863

Assay

≥97.0% (HPLC)

Form

powder or crystals

Farbe

white

mp (Schmelzpunkt)

76-80 °C

Anwendung(en)

cell analysis

Lagertemp.

2-8°C

SMILES String

CCCC(=O)NC1CCSC1=O

InChI

1S/C8H13NO2S/c1-2-3-7(10)9-6-4-5-12-8(6)11/h6H,2-5H2,1H3,(H,9,10)

InChIKey

IMJUOGHALGXOSS-UHFFFAOYSA-N

Anwendung

Induziert die Expression von Violacein in einer Chromobacterium violaceum-Mutante, die kein Homoserinlacton produziert (Lit. K.H. McClean et al. Microbiology 143, 3703 (1997)

Biochem./physiol. Wirkung

N-Butyryl-DL-homocysteine thiolactone is a butylated derivative of homocysteine thiolactone which is used to induce hyperhomocysteinemia and seizures.

Lagerklassenschlüssel

13 - Non Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)

Analysenzertifikate (COA)

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DL-Homocystein ≥95% (titration)

Sigma-Aldrich

H4628

DL-Homocystein

HYPERHOMOCYSTEINAEMIA-INDUCED CARDIOVASCULAR CHANGES IN RATS.
Resstel LB, de Andrade CR, et al.
Clinical and Experimental Pharmacology & Physiology, 35, 949-956 (2008)
Claudia Roberta de Andrade et al.
Vascular pharmacology, 53(3-4), 99-106 (2010-05-11)
We aimed to investigate the vascular effects of hyperhomocysteinemia (HHcy) on carotid arteries from young and adult rats. With this purpose young and adult rats received a solution of DL-homocysteine-thiolactone (1 g/kg body weight/day) in the drinking water for 7
N V Zaichko
Ukrains'kyi biokhimichnyi zhurnal (1999 ), 82(2), 59-66 (2010-08-06)
Influence of DL-homocysteine thiolactone loading (100 mg/kg by intragastric administration for 28 days) on enzymes activity of adenylic nucleotide and adenosine metabolism in the blood serum, platelets and liver of rats was investigated. The relation between revealed disturbance and platelet
Aleksandra Rašić Marković et al.
Cellular and molecular neurobiology, 31(8), 1221-1228 (2011-06-23)
Numerous studies have linked folate deficiency and resultant elevated plasma homocysteine levels with an increased risk of neurodegenerative diseases and seizures. The aim of the present study was to examine the effect of acute folic acid administration on behavioural and
K H McClean et al.
Microbiology (Reading, England), 143 ( Pt 12), 3703-3711 (1998-01-09)
Quorum sensing relies upon the interaction of a diffusible signal molecule with a transcriptional activator protein to couple gene expression with cell population density. In Gram-negative bacteria, such signal molecules are usually N-acylhomoserine lactones (AHLs) which differ in the structure

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