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S1900000

Sulfadimidin

European Pharmacopoeia (EP) Reference Standard

Synonym(e):

Sulfamethazin, 4,6-Dimethylsulfadiazin, 4-Amino-N-(4,6-dimethyl-2-pyrimidinyl)-benzolsulfonamid, Sulfadimethyldiazin, Sulfadimidin

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About This Item

Empirische Formel (Hill-System):
C12H14N4O2S
CAS-Nummer:
57-68-1
Molekulargewicht:
278.33
Beilstein:
261304
MDL-Nummer:
MFCD00006066
UNSPSC-Code:
41116107
PubChem Substanz-ID:
329824495
NACRES:
NA.24

Qualität

pharmaceutical primary standard

API-Familie

sulfadimidine

Hersteller/Markenname

EDQM

Anwendung(en)

pharmaceutical (small molecule)

Format

neat

Lagertemp.

2-8°C

SMILES String

Cc1cc(C)nc(NS(=O)(=O)c2ccc(N)cc2)n1

InChI

1S/C12H14N4O2S/c1-8-7-9(2)15-12(14-8)16-19(17,18)11-5-3-10(13)4-6-11/h3-7H,13H2,1-2H3,(H,14,15,16)

InChIKey

ASWVTGNCAZCNNR-UHFFFAOYSA-N

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Allgemeine Beschreibung

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Anwendung

Sulfadimidine EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Biochem./physiol. Wirkung

Ein antimikrobieller Schwefelwirkstoff. Induziert die CYP3A4-Expression und wird acetyliert durch N-Acetyltransferase. Weist geschlechtsabhängige Pharmakokinetik auf, metabolisiert durch die maskuline Isofrom CYP2C11.

Verpackung

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Sonstige Hinweise

Sales restrictions may apply.

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Produkt-Nr.
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Preisangaben

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 2

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Analysenzertifikate (COA)

Lot/Batch Number

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L A Poirier et al.
Regulatory toxicology and pharmacology : RTP, 30(3), 217-222 (2000-01-06)
Recently, changes have been proposed in the criteria historically used in the evaluation of the applicability to humans of some of the results obtained from the rodent carcinogenicity bioassay data. These questions center on the suitability of the rodent model
Anna Gulkowska et al.
Chemosphere, 107, 366-372 (2014-01-28)
Soil incubation experiments using (14)C-labelled sulfamethazine were carried out to assess the factors governing its nonextractable residue (NER) formation via nucleophilic addition reactions. Circumstantial evidence on possible mechanisms of NER formation was derived from a selective manipulation of soil samples.
Astrid Bienert-Zeit et al.
American journal of veterinary research, 76(4), 318-327 (2015-03-31)
To monitor concentrations of sulfadimidine in the paranasal sinus mucosa (PSM) of unsedated horses following IV administration of trimethoprim-sulfadimidine via in vivo microdialysis. 10 healthy adult horses. Concentric microdialysis probes were implanted into the subepithelial layers of the frontal sinus
Zhe Meng et al.
Food chemistry, 174, 597-605 (2014-12-23)
A novel UPLC-MS/MS method for quantification and confirmation of eight fluoroquinolones, five sulphonamides (SAs) and four acetyled metabolites in milk is developed. Their main fragmentation pathways were presented. The limits of quantification were in the range of 0.01-0.29 μg kg(-1)
Jie Hou et al.
Environmental science and pollution research international, 22(6), 4545-4554 (2014-10-17)
A feasible and rapid analysis for the simultaneous determination of sulfonamides (SAs), tetracyclines (TCs), fluoroquinolones (FQs), macrolides (MACs) and nitrofurans (NFs) in livestock manure and soils was established by solid-phase extraction (SPE)-ultra-performance liquid chromatography (UPLC)-tandem mass spectrometry (MS/MS). A total
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