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Merck

PHR1554

Supelco

Heptan

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(e):

Heptane

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About This Item

Lineare Formel:
CH3(CH2)5CH3
CAS-Nummer:
Molekulargewicht:
100.20
Beilstein:
1730763
EG-Nummer:
MDL-Nummer:
UNSPSC-Code:
41116107
PubChem Substanz-ID:
NACRES:
NA.24

Qualität

certified reference material
pharmaceutical secondary standard

Qualitätsniveau

Agentur

traceable to USP 1304209

Dampfdichte

3.5 (vs air)

Dampfdruck

40 mmHg ( 20 °C)
83 mmHg ( 37.7 °C)

Analysenzertifikat (CofA)

current certificate can be downloaded

Selbstzündungstemp.

433 °F

Expl.-Gr.

7 %

Verpackung

ampule of 3x1.2 mL each

Methode(n)

HPLC: suitable
gas chromatography (GC): suitable

Brechungsindex

n20/D 1.387 (lit.)

bp

98 °C (lit.)

mp (Schmelzpunkt)

−91 °C (lit.)

Dichte

0.684 g/mL at 25 °C (lit.)

Anwendung(en)

pharmaceutical (small molecule)

Format

neat

Lagertemp.

2-30°C

SMILES String

CCCCCCC

InChI

1S/C7H16/c1-3-5-7-6-4-2/h3-7H2,1-2H3

InChIKey

IMNFDUFMRHMDMM-UHFFFAOYSA-N

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Allgemeine Beschreibung

Heptane is a non-polar organic solvent and a straight-chain alkane with seven carbon atoms. It is generally employed in the synthesis of pharmaceuticals and considered to be one of the green solvents.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Anwendung

Heptane may be used as a pharmaceutical reference solvent standard for the determination of the analyte in bulk drug and pharmaceutical formulations by gas chromatography.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Hinweis zur Analyse

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Sonstige Hinweise

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Fußnote

To see an example of a Certificate of Analysis for this material enter LRAC0594 in the slot below. This is an example certificate only and may not be the lot that you receive.

Empfohlene Produkte

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

Signalwort

Danger

Gefahreneinstufungen

Aquatic Acute 1 - Aquatic Chronic 1 - Asp. Tox. 1 - Flam. Liq. 2 - Skin Irrit. 2 - STOT SE 3

Zielorgane

Central nervous system

Lagerklassenschlüssel

3 - Flammable liquids

WGK

WGK 2

Flammpunkt (°F)

24.8 °F - closed cup

Flammpunkt (°C)

-4 °C - closed cup


Choose from one of the most recent versions:

Analysenzertifikate (COA)

Lot/Batch Number

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If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

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Green process chemistry in the pharmaceutical industry
Cue BW and Zhang J
Green Chemistry Letters and Reviews, 2(4), 193-211 (2009)
What is a green solvent? A comprehensive framework for the environmental assessment of solvents
Capello C, et al.
Green Chemistry, 9(9), 927-934 (2007)
?467? Residual Solvents
USP43/NF38: United States Pharmacopeia and National Formulary
United States Pharmacopeia/National Formulary, 45(3), 6712-6712 (2019)
A generic static headspace gas chromatography method for determination of residual solvents in drug substance.
Cheng, et al.
Journal of Chromatography A, 1217(41), 6413-6421 (2010)
Gábor Csordás et al.
PloS one, 9(6), e98191-e98191 (2014-06-04)
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