PHR1296
Bifonazol
Pharmaceutical Secondary Standard; Certified Reference Material
Synonym(e):
1-(p,α-Diphenylbenzyl)-imidazol
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Alle Fotos(1)
About This Item
Empirische Formel (Hill-System):
C22H18N2
CAS-Nummer:
Molekulargewicht:
310.39
EG-Nummer:
MDL-Nummer:
UNSPSC-Code:
41116107
PubChem Substanz-ID:
NACRES:
NA.24
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Qualität
certified reference material
pharmaceutical secondary standard
Qualitätsniveau
Agentur
traceable to Ph. Eur. B1110000
API-Familie
bifonazole
Analysenzertifikat (CofA)
current certificate can be downloaded
Methode(n)
HPLC: suitable
gas chromatography (GC): suitable
Anwendung(en)
pharmaceutical (small molecule)
Format
neat
Lagertemp.
2-8°C
SMILES String
c1ccc(cc1)C(c2ccc(cc2)-c3ccccc3)n4ccnc4
InChI
1S/C22H18N2/c1-3-7-18(8-4-1)19-11-13-21(14-12-19)22(24-16-15-23-17-24)20-9-5-2-6-10-20/h1-17,22H
InChIKey
OCAPBUJLXMYKEJ-UHFFFAOYSA-N
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Allgemeine Beschreibung
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Bifonazole is a substituted imidazole analog with therapeutic potential in treating invasive mucosal infections. It exhibits antifungal activity by suppressing the proliferation of dermatophytes, yeasts and fungi affecting the skin and nails. Its mode of action involves blocking the fungal ergosterol biosynthetic pathway and additional inhibition of terpenoid biosynthesis.
Bifonazole is a substituted imidazole analog with therapeutic potential in treating invasive mucosal infections. It exhibits antifungal activity by suppressing the proliferation of dermatophytes, yeasts and fungi affecting the skin and nails. Its mode of action involves blocking the fungal ergosterol biosynthetic pathway and additional inhibition of terpenoid biosynthesis.
Anwendung
Bifonazole may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using spectrophotometric technique.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Biochem./physiol. Wirkung
Bifonazol ein Imidazol-basiertes Antipilzmittel mit einem breiten Wirkspektrum gegen viele Pilze, Schimmel, Hefen und einige Gram-positive Bakterien. Bifonazol hemmt Ergosterol Biosynthetic Protein 28 und Cytochrom P450 2B4.
Hinweis zur Analyse
These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.
Sonstige Hinweise
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
Fußnote
To see an example of a Certificate of Analysis for this material enter LRAC3256 in the slot below. This is an example certificate only and may not be the lot that you receive.
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Signalwort
Warning
H-Sätze
Gefahreneinstufungen
Acute Tox. 4 Oral
Lagerklassenschlüssel
11 - Combustible Solids
WGK
WGK 1
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
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Validated spectrophotometric methods for the determination of bifonazole in pharmaceuticals by charge transfer complexation
Ismail SBN, et al.
Journal of the Association of Arab Universities for Basic and Applied Sciences, 19(1), 8-14 (2016)
Determination of bifonazole in creams containing methyl-and propyl p-hydroxybenzoate by derivative spectrophotometric method
Popovic G, et al.
Journal of Pharmaceutical and Biomedical Analysis, 33(1), 131-136 (2003)
Yonghong Zhao et al.
The Journal of biological chemistry, 281(9), 5973-5981 (2005-12-24)
To better understand ligand-induced structural transitions in cytochrome P450 2B4, protein-ligand interactions were investigated using a bulky inhibitor. Bifonazole, a broad spectrum antifungal agent, inhibits monooxygenase activity and induces a type II binding spectrum in 2B4dH(H226Y), a modified enzyme previously
Salomé El Hage et al.
Archiv der Pharmazie, 344(6), 402-410 (2011-03-25)
Two series of chlorinated benzhydryl imidazole and triazole derivatives were synthesized and tested in vitro against representative strains of potent pathogenic bacteria (Staphylococcus aureus CIP 4.83, Escherichia hirae CIP 5855, Pseudomonas aeruginosa CIP 82118, Escherichia coli CIP 53126) and fungi
Shinichi Watanabe et al.
Mycoses, 49(3), 236-241 (2006-05-10)
The aim of the study was to compare the efficacy and safety of luliconazole 1% cream and bifonazole 1% cream as applied in the treatment of tinea pedis (interdigital-type and plantar-type). A multi-clinic, randomised single-blind, parallel group study with 34
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