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Dokumente

D8255

Sigma-Aldrich

1,4-Dithioerythritol

≥99.0%

Synonym(e):

erythro-1,4-Dimercapto-2,3-butanediol, erythro-2,3-Dihydroxy-1,4-butanedithiol, Cleland Reagens, DTE

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About This Item

Lineare Formel:
HSCH2CH(OH)CH(OH)CH2SH
CAS-Nummer:
6892-68-8
Molekulargewicht:
154.25
Beilstein:
1719756
EG-Nummer:
229-998-8
MDL-Nummer:
MFCD00063750
UNSPSC-Code:
12352201
PubChem Substanz-ID:
24894199
NACRES:
NA.21

Qualitätsniveau

300

Assay

≥99.0%

Form

powder

Eignung der Reaktion

reagent type: reductant

pH-Wert

4.5-6.5 (25 °C, 15.4 g/L)

mp (Schmelzpunkt)

82-84 °C (lit.)

Lagertemp.

2-8°C

SMILES String

O[C@@H](CS)[C@H](O)CS

InChI

1S/C4H10O2S2/c5-3(1-7)4(6)2-8/h3-8H,1-2H2/t3-,4+

InChIKey

VHJLVAABSRFDPM-ZXZARUISSA-N

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Verwandte Kategorien

Anwendung

Reagenz zum Erhalten der −SH-Gruppen im reduzierten Zustand; sorgt für eine quantitative Reduzierung der Disulfide

Piktogramme

Exclamation mark
GHS07

Signalwort

Warning

H-Sätze

H302,H412

Gefahreneinstufungen

Acute Tox. 4 Oral - Aquatic Chronic 3

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Persönliche Schutzausrüstung

dust mask type N95 (US), Eyeshields, Gloves

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Analysenzertifikate (COA)

Lot/Batch Number
0000375638
0000375637
0000373102
0000373104
0000373103

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Colin M Cleary et al.
eLife, 9 (2020-09-15)
Respiratory chemoreceptors regulate breathing in response to changes in tissue CO2/H+. Blood flow is a fundamental determinant of tissue CO2/H+, yet little is known regarding how regulation of vascular tone in chemoreceptor regions contributes to respiratory behavior. Previously, we showed
Muzamil M Z Noorani et al.
Frontiers in physiology, 2, 42-42 (2011-08-04)
Transient receptor potential (TRP) C1 and C3 (TRPC1 and TRPC3) are expressed in vascular smooth muscle cells and are thought to be involved in vascular contractility. In the present study, we determined the effect of systemic hypertension on TRPC1/TRPC3 channel
Christopher J Garland et al.
Science signaling, 10(486) (2017-07-06)
Vascular smooth muscle contraction is suppressed by feedback dilation mediated by the endothelium. In skeletal muscle arterioles, this feedback can be activated by Ca2+ signals passing from smooth muscle through gap junctions to endothelial cells, which protrude through holes in
Vishal R Yadav et al.
American journal of physiology. Lung cellular and molecular physiology, 314(5), L724-L735 (2018-02-02)
Hypoxia-induced pulmonary vasoconstriction (HPV) is attributed to an increase in intracellular Ca2+ concentration ([Ca2+]i) in pulmonary artery smooth muscle cells (PASMCs). We have reported that phospholipase C-γ1 (PLCγ1) plays a significant role in the hypoxia-induced increase in [Ca2+]i in PASMCs
Stephen Shrum et al.
Biomolecules, 9(12) (2019-12-11)
Kidneys from deceased donors used for transplantation are placed in cold storage (CS) solution during the search for a matched recipient. However, CS causes mitochondrial injury, which may exacerbate renal graft dysfunction. Here, we explored whether adding NS11021, an activator
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