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Merck

D8064

Sigma-Aldrich

4-(2-(6-(Dibutylamino)-2-naphthalenyl)ethenyl)-1-(3-sulfopropyl)pyridiniumhydroxid Inneres Salz

≥95% purity (HPLC), solid

Synonym(e):

Di-4-ANEPPS

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About This Item

Empirische Formel (Hill-System):
C28H36N2O3S
CAS-Nummer:
Molekulargewicht:
480.66
MDL-Nummer:
UNSPSC-Code:
12171500
PubChem Substanz-ID:
NACRES:
NA.47

product name

4-(2-(6-(Dibutylamino)-2-naphthalenyl)ethenyl)-1-(3-sulfopropyl)pyridiniumhydroxid Inneres Salz, ≥95% (HPLC), solid

Qualitätsniveau

Assay

≥95% (HPLC)

Form

solid

Mol-Gew.

480.66

Farbe

orange to dark red

Löslichkeit

DMF: soluble
DMSO: soluble
ethanol: soluble

ε (Extinktionskoeffizient)

≥38000 at 493-499 nm in methanol

Anwendung(en)

diagnostic assay manufacturing
hematology
histology

Lagertemp.

2-8°C

SMILES String

CCCCN(CCCC)c1ccc2cc(\C=C\c3cc[n+](CCCS([O-])(=O)=O)cc3)ccc2c1

InChI

1S/C28H36N2O3S/c1-3-5-17-30(18-6-4-2)28-13-12-26-22-25(10-11-27(26)23-28)9-8-24-14-19-29(20-15-24)16-7-21-34(31,32)33/h8-15,19-20,22-23H,3-7,16-18,21H2,1-2H3

InChIKey

HAPJROQJVSPKCJ-UHFFFAOYSA-N

Anwendung

4-(2-(6-(Dibutylamino)-2-naphthalenyl)ethenyl)-1-(3-sulfopropyl)pyridinium hydroxide inner salt has been used as a voltage sensitive dye in cardiac cells.

Biochem./physiol. Wirkung

Membranpotential Farbstoff, der auf Änderungen des Membranpotentials, angezeigt durch Fluoreszenzanregungs-Veränderungen bei 440 und 505 nm, reagiert; korreliert zu Veränderungen im Membranpotential der Zelle.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)


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Nature, 355(6358), 349-351 (1992-01-23)
Excitable media can support spiral waves rotating around an organizing centre. Spiral waves have been discovered in different types of autocatalytic chemical reactions and in biological systems. The so-called 're-entrant excitation' of myocardial cells, causing the most dangerous cardiac arrhythmias
G Bub et al.
American journal of physiology. Heart and circulatory physiology, 298(5), H1616-H1625 (2010-03-17)
Sarcomere length (SL) is an important determinant and indicator of cardiac mechanical function; however, techniques for measuring SL in living, intact tissue are limited. Here, we present a technique that uses two-photon microscopy to directly image striations of living cells
Katharine M Dibb et al.
Circulation. Heart failure, 2(5), 482-489 (2009-10-08)
In ventricular myocytes, the majority of structures that couple excitation to the systolic rise of Ca(2+) are located at the transverse tubular (t-tubule) membrane. In the failing ventricle, disorganization of t-tubules disrupts excitation contraction coupling. The t-tubule membrane is virtually
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cAMP is a positive regulator tightly involved in certain types of synaptic plasticity and related memory functions. However, its spatiotemporal roles at the synaptic and neural circuit levels remain elusive. Using a combination of a cAMP optogenetics approach and voltage-sensitive
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Activity-dependent changes in the input-output (I-O) relationship of a neural circuit are central in the learning and memory function of the brain. To understand circuit-wide adjustments, optical imaging techniques to probe the membrane potential at every component of neurons, such

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