ALD00602

(–)-PSI Reagent

95%

• Synonym(e): (2S,3aS,6R,7aS)-3a-Methyl-2-((perfluorophenyl)thio)-6-(prop-1-en-2-yl)hexahydrobenzo[d][1,3,2]oxathiaphosphole 2-sulfide, (–)-Ψ, Phosphorus-Sulfur Incorporation Reagent
• Empirische Formel (Hill-System): C₁₆H₁₆F₅OPS₃
• CAS-Nummer: 2245335-70-8
• Molekulargewicht: 446.46
• MDL-Nummer: MFCD32068365
• UNSPSC-Code: 12352101
• NACRES: NA.22

Eigenschaften

• Assay: 95%
• Form: powder or crystals
• mp (Schmelzpunkt): 103-107 °C
• SMILES String: Fc1c(c(c(c(c1F)F)S[P]2(=S)S[C@@]3([C@@H](O2)C[C@@H](CC3)C(=C)C)C)F)F
• InChI: 1S/C16H16F5OPS3/c1-7(2)8-4-5-16(3)9(6-8)22-23(24,26-16)25-15-13(20)11(18)10(17)12(19)14(15)21/h8-9H,1,4-6H2,2-3H3/t8-,9+,16+,23?/m1/s1
• InChIKey: YPYCUYPOHPPYAS-QSHUGKRNSA-N

Beschreibung

Anwendung

Air- and moisture-tolerant, this (-)-PSI Reagent was developed in the Baran lab for stereocontrolled synthesis of phosphorothioate oligonucleotides. The enantiomer, (+)-PSI Reagent, is also available (cat# ALD00604).
The PSI Reagents open access to thiophosphate-based nucleotide molecules with therapeutic promise as demonstrated by the Baran lab in the preparation of pure stereoisomers of cyclic dinucleotides (CDNs) and antisense oligonucleotides (ASOs).

Learn more about PI and PSI reagents

Sonstige Hinweise

Unlocking P(V): Reagents for chiral phosphorothioate synthesis

PSI on OpenFlask

Rechtliche Hinweise

PCT/US2019/027256; U.S. Nonprovisional Patent Application #16/382,692

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable