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70127

Sigma-Aldrich

Naloxon -hydrochlorid Dihydrat

≥99.0% (TLC)

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About This Item

Empirische Formel (Hill-System):
C19H21NO4 · HCl · 2H2O
CAS-Nummer:
51481-60-8
Molekulargewicht:
399.87
Beilstein:
6260807
EG-Nummer:
201-447-6
MDL-Nummer:
MFCD00150901
UNSPSC-Code:
12352202

Assay

≥99.0% (TLC)

Lagertemp.

2-8°C

SMILES String

O.O.Cl.Oc1ccc2C[C@H]3N(CC[C@@]45[C@@H](Oc1c24)C(=O)CC[C@@]35O)CC=C

InChI

1S/C19H21NO4.ClH.2H2O/c1-2-8-20-9-7-18-15-11-3-4-12(21)16(15)24-17(18)13(22)5-6-19(18,23)14(20)10-11;;;/h2-4,14,17,21,23H,1,5-10H2;1H;2*1H2/t14-,17+,18+,19-;;;/m1.../s1

InChIKey

TXMZWEASFRBVKY-IOQDSZRYSA-N

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Anwendung

Displaces morphine and other opiate agonists from the opiate receptor. In studies on the opiate receptor[1][2]

Sonstige Hinweise

Potent opiate antagonist. Displaces morphine and other opiate agonists from the opiate receptor. In studies on the opiate receptor[1][2]

Piktogramme

Exclamation mark
GHS07

Signalwort

Warning

Gefahreneinstufungen

Aquatic Chronic 4 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Lagerklassenschlüssel

13 - Non Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

dust mask type N95 (US), Eyeshields, Gloves

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Analysenzertifikate (COA)

Lot/Batch Number

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C Mollereau et al.
The Journal of biological chemistry, 263(34), 18003-18008 (1988-12-05)
When assayed for specific opiate binding in the presence of 120 mM NaCl, digitonin extracts from frog (Rana ridibunda) brain membranes were found to contain about the same quantity (0.5 pmol/mg of protein) of high (Kdh = 0.4 nM) and
T Costa et al.
Proceedings of the National Academy of Sciences of the United States of America, 86(19), 7321-7325 (1989-10-01)
According to classical models of drug-receptor interactions, competitive antagonists share with agonists the ability to bind to a common site on the receptor molecule. However, they are different from agonists, as they cannot trigger the "stimulus" that leads to biological
Yumei Liu et al.
PloS one, 8(1), e51573-e51573 (2013-02-06)
Previously, we demonstrated that electroacupuncture (EA) decreased lymphocyte infiltration into the spinal cords of rats presenting with experimental autoimmune encephalomyelitis (EAE), a disease model used in the study of multiple sclerosis (MS). The aim of this study was to characterize
Delia Aguado et al.
Anesthesiology, 118(5), 1160-1169 (2013-02-15)
Opioid antagonists at ultra-low doses have been used with opioid agonists to prevent or limit opioid tolerance. The aim of this study was to evaluate whether an ultra-low dose of naloxone combined with remifentanil could block opioid-induced hyperalgesia and tolerance
Opiate receptor antagonists for treatment of severe pruritus associated with advanced cholestatic liver disease.
Nilay Kumar et al.
Journal of palliative medicine, 16(2), 122-123 (2013-02-09)
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