383376

Kaliumantimonyltartrat Trihydrat

ACS reagent, ≥99%

• Synonym(e): Antimonkaliumtartrat, Brechweinstein (Kali)
• Empirische Formel (Hill-System): C₈H₄K₂O₁₂Sb₂ · 3H₂O
• CAS-Nummer: 28300-74-5
• Molekulargewicht: 667.87
• EG-Nummer: 234-293-3
• MDL-Nummer: MFCD00167056
• UNSPSC-Code: 12352100
• PubChem Substanz-ID: 24863959
• NACRES: NA.21

Eigenschaften

• Qualität: ACS reagent
• Qualitätsniveau: 200
• Assay: ≥99%; 99.0-103.0%
• Form: powder
• Verunreinigungen: ≤0.020 meq/g Titr. acid or base
• Verlust: ≤2.7% loss on drying
• mp (Schmelzpunkt): ≥300 °C (lit.)
• Löslichkeit: water: soluble
• Kationenspuren: As: ≤0.015%
• SMILES String: O.O.O.[K+].[K+].O=C1O[Sb-]23OC1C4O[Sb-]5(OC(C(O2)C(=O)O3)C(=O)O5)OC4=O
• InChI: 1S/2C4H4O6.2K.3H2O.2Sb/c2*5-1(3(7)8)2(6)4(9)10;;;;;;;/h2*1-2H,(H,7,8)(H,9,10);;;3*1H2;;/q2*-2;2*+1;;;;2*+3/p-4
• InChIKey: WBTCZEPSIIFINA-UHFFFAOYSA-J

Beschreibung

Allgemeine Beschreibung

Potassium antimonyl tartrate trihydrate is a metalloid salt in which the antimony is in trivalent state (SbIII). Potassium antimonyl tartrate (PAT) is an antiparasitic agent predominantly used for treating infections caused by the parasite Leishmania. Its antiangiogenic and antitumor properties has been investigated in nonsmall-cell lung cancer (NSCLC) cells. Studies in Chinese hamster ovary cells show that it may prevent the repair of DNA double strand breaks (DSBs) caused by γ-irradiation.

Anwendung

Potassium antimonyl tartrate trihydrate has been used in the dose-inhibition experiments to evaluate the dose-inhibition curves of antimony-based antileishmanial compounds against Leishmania promastigotes in medium 199.

Potassium antimonyl tartrate trihydrate may be used to prepare antimony (Sb(III)) stock solution in deionized water (100mg/L). It may also be employed in the spectrophotometric determination of total phosphorus in dry sediments.

Sicherheitshinweise

• Piktogramme: GHS06,GHS09
• Signalwort: Danger
• H-Sätze: H301,H315,H317,H332,H411
• P-Sätze: P261 - P273 - P280 - P301 + P310 - P302 + P352 - P304 + P340 + P312
• Gefahreneinstufungen: Acute Tox. 3 Oral - Acute Tox. 4 Inhalation - Aquatic Chronic 2 - Skin Irrit. 2 - Skin Sens. 1
• Lagerklassenschlüssel: 6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Faceshields, Gloves