Specific for the NMDAR1 containing the C2′ splice variant insert. The antibody does not recognize the NMDAR1 subunits of the NMDA receptor that do not contain the C2′ insert. By Western blot the antibody recognizes a protein with molecular weight of 120 kDa. Also labels a single higher molecular weight band that may be a posttranslationally modified form of the protein.
Immunogen
Peptide corresponding to the C-terminus of the rat NMDAR1 C2′ splice variant.
Anwendung
Research Category Neurowissenschaft
Research Sub Category Neurotransmitter & Rezeptoren
Detect NMDAR1 Splice Variant C2 using this Anti-NMDAR1 Splice Variant C2 Antibody validated for use in IH & WB.
Western blot: 1:2000 using ECL
Immunohistochemistry: 1:1000
Optimal working dilutions must be determined by the end user.
Physikalische Form
Affinity purified immunoglobulin. Lyophilized from ammonium bicarbonate (5 mM) so some residual salt may also be present. Reconstitute with 50 μL of PBS. Contains no preservatives.
Lagerung und Haltbarkeit
Maintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles.
Rechtliche Hinweise
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Haftungsausschluss
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Lagerklassenschlüssel
11 - Combustible Solids
WGK
WGK 1
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Functional and structural alterations of clustered postsynaptic ligand gated ion channels in neuronal cells are thought to contribute to synaptic plasticity and memory formation in the human brain. Here, we describe a novel molecular mechanism for structural alterations of NR1
Intrauterine growth restriction due to uteroplacental insufficiency decreased white matter and altered NMDAR subunit composition in juvenile rat hippocampi.
American Journal of Physiology. Regulatory, Integrative and Comparative Physiology null
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