5.33574

TRPML3 Activator, ML123

• Synonym(e): TRPML3 Activator, ML123, 4-Chloro-N-(2-morpholinocyclohexyl)benzenesulfonamide, SF-21, CID2911646, ML123, ML 123, Transient Receptor Potential Channel 3 Activator, SID24801657, Racemate, SR-1984
• Empirische Formel (Hill-System): C₁₆H₂₃ClN₂O₃S
• CAS-Nummer: 384352-24-3
• Molekulargewicht: 358.88
• MDL-Nummer: MFCD02172356
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 2911646
• NACRES: NA.77

Eigenschaften

• Assay: ≥92% (HPLC)
• Qualitätsniveau: 100
• Form: solid
• Hersteller/Markenname: Calbiochem^®
• Lagerbedingungen: OK to freeze; protect from light
• Farbe: off-white
• Löslichkeit: DMSO: 50 mg/mL
• Lagertemp.: 2-8°C
• SMILES String: C1CCC(C(C1)NS(=O)(=O)C2=CC=C(C=C2)Cl)N3CCOCC3
• InChIKey: AYQCZQKMGKDZPS-UHFFFAOYSA-N

Beschreibung

Allgemeine Beschreibung

A non-cytotoxic morpholinyl-cyclohexylbenzenesulfonamide compound that acts as a selective agonist of TRPML3 channel (EC₅₀ = 873 nM in hTRPML3-YPF transfected HEK293 cells). Displays significantly weaker agonistic activity for TRPML2 channel (54.5% at 10 µM) and is shown to be inactive against hTRPML1, hTRPM2, mTRPV2, hTRPC3, drTRPN1, and hTRPA1 (~10 µM). Also binds to sigma-1 receptor at much higher concentrations (IC₅₀ = 31 µM).

Biochem./physiol. Wirkung

Cell permeable: yes

Primary Target
TRPML3

Reversible: yes

Verpackung

Packaged under inert gas

Warnhinweis

Toxicity: Standard Handling (A)

Rekonstituierung

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Sonstige Hinweise

Antolin, A.A., and Mestres, J. 2015. ACS Chem. Biol.10, 395.

Grimm, C., et al. 2012. J. Biol. Chem.287, 22701.
Saldanha, S., et al. 2010. Probe Reports from the NIH Molecular Libraries Program.
Grimm, C., et al. 2010. Chem. Biol.17, 135.

Rechtliche Hinweise

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H315 - H319 - H335
• P-Sätze: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Gefahreneinstufungen: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Zielorgane: Respiratory system
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable