513024-M

PD 151746

A cell-permeable, non-peptidic, and highly selective calpain inhibitor directed towards the calcium binding sites of calpain.

• Synonym(e): PD 151746, 3-(5-Fluoro-3-indolyl)-2-mercapto-(Z)-2-propenoic Acid
• Empirische Formel (Hill-System): C₁₁H₈FNO₂
• CAS-Nummer: 179461-52-0
• Molekulargewicht: 205.19
• MDL-Nummer: MFCD03453564
• UNSPSC-Code: 12352200

Eigenschaften

• Assay: ≥95% (HPLC)
• Form: solid
• Hersteller/Markenname: Calbiochem^®
• Lagerbedingungen: OK to freeze; protect from light
• Farbe: orange
• Löslichkeit: DMSO: 200 mg/mL; methanol: 5 mg/mL
• Lagertemp.: −20°C
• InChI: 1S/C11H8FNO2S/c12-7-1-2-9-8(4-7)6(5-13-9)3-10(16)11(14)15/h1-5,13,16H,(H,14,15)/b10-3-
• InChIKey: HWMQHECFXSVZGN-KMKOMSMNSA-N

Beschreibung

Allgemeine Beschreibung

A cell-permeable, non-peptidic, and highly selective calpain inhibitor directed towards the calcium binding sites of calpain. Displays over 20-fold greater selectivity for calpain-1 (Cat. Nos. 208712 and 208713) over calpain-2 (Cat. Nos. 208715 and 208718) (K_i values: 260 nM and 5.33 µM, respectively). Has been shown to prevent cycloheximide-induced apoptosis.

Biochem./physiol. Wirkung

Primary Target
calpain-1

Target K_i: 260 nM against calpain-1

Warnhinweis

Toxicity: Standard Handling (A)

Rekonstituierung

Unstable in solution; reconstitute just prior to use.

Sonstige Hinweise

Squier, M.K., et al. 1999. J. Cell Physiol.178, 311.
Wang, K.K., et al. 1996. Proc. Natl. Acad. Sci. USA93, 6687.

Rechtliche Hinweise

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable