5.08436

AEBSF Hydrochloride

InSolution, ≥97%, Specific, irreversible inhibitor of serine proteases

• Synonym(e): InSolution AEBSF, Hydrochloride, 4-(2-Aminoethyl)benzenesulfonylfluoride, HCl, 4-(2-Aminoethyl)benzene-1-sulfonylfluoride, HCl, AEBSF, HCl InSolution
• Empirische Formel (Hill-System): C₈H₁₀FNO₂S · xHCl
• CAS-Nummer: 30827-99-7
• Molekulargewicht: 203.23 (free base basis)
• MDL-Nummer: MFCD00132962
• UNSPSC-Code: 12352202
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥97% (HPLC)
• Form: liquid
• Hersteller/Markenname: Calbiochem^®
• Lagerbedingungen: OK to freeze; avoid repeated freeze/thaw cycles; protect from light
• Lagertemp.: −70°C
• InChI: 1S/C8H10FNO2S.ClH/c9-13(11,12)8-3-1-7(2-4-8)5-6-10;/h1-4H,5-6,10H2;1H
• InChIKey: WRDABNWSWOHGMS-UHFFFAOYSA-N

Beschreibung

Allgemeine Beschreibung

Specific, irreversible inhibitor of serine proteases. Inhibits chymotrypsin, kallikrein, plasmin, thrombin, trypsin, and related thrombolytic enzymes. Stable, nontoxic alternative to PMSF (Cat. No. 52332) and DFP (Cat. No. 30967). A β-secretase inhibitor that inhibits β-amyloid peptide (Aβ) production and enhances amyloid precursor protein (sAPPU_α) secretion in several cell lines at millimolar concentrations. Use at the same molar concentrations (0.1-1.0 mM) as PMSF for most applications.

Biochem./physiol. Wirkung

Reversible: no

Verpackung

Packaged under inert gas

Warnhinweis

Toxicity: Standard Handling (A)

Physikalische Form

A 50 mM (50 mg/4.17 ml) sterile-filtered solution of AEBSF, Hydrochloride (Cat. No. 101500) in H₂O.

Rekonstituierung

Following initial thaw, aliquot and freeze (-20°C). Aliquots are stable for up to 1 year at -20°C.

Sonstige Hinweise

Citron, M., et al. 1996. Neuron17, 171.
Ohkubo, I., et al. 1994. J. Biochem.116, 1182.
Mintz, G.R. 1993. BioPharm.6, 34.
Lawson, W.B., et al. 1982. Folia Haematol.109, 52.
Markwardt, F., et al. 1974. Biochem. Pharmacol.23, 2247.
Markwardt, F., et al. 1973. Thromb. Res.2, 343.

Baker, B.R., and Cory, M. 1971. J. Med. Chem.14, 119.

Rechtliche Hinweise

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H315 - H319
• P-Sätze: P264 - P280 - P302 + P352 - P305 + P351 + P338 - P332 + P313 - P337 + P313
• Gefahreneinstufungen: Eye Irrit. 2 - Skin Irrit. 2
• Lagerklassenschlüssel: 12 - Non Combustible Liquids
• WGK: WGK 2
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable