5.08410
Glycogen Phosphorylase Inhibitor II, KB228
Synonym(e):
Glycogen Phosphorylase Inhibitor II, KB228, KB-228
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About This Item
Empirische Formel (Hill-System):
C16H22N2O7
CAS-Nummer:
Molekulargewicht:
354.36
MDL-Nummer:
UNSPSC-Code:
51111800
NACRES:
NA.77
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Assay
≥98% (HPLC)
Qualitätsniveau
Form
powder
Wirksamkeit
930 nM Ki
Hersteller/Markenname
Calbiochem®
Lagerbedingungen
OK to freeze
protect from light
Farbe
white
Löslichkeit
DMSO: 100 mg/mL
Lagertemp.
−20°C
Allgemeine Beschreibung
A glucopyranosyl urea compound that acts as an inhibitor of muscle glycogen phosphorylase (Ki = 930 nM). Displays a mixed type of inhibition. Enhances glucose sensitivity in chow-fed, obese, diabetic mice and increasing hepatic glucose uptake. Reduces blood glucose levels and increases hepatic glycogen content in C57/BL6J mice. Shown to increase mitochondrial oxidation in Hep2G cells under normoglycemic conditions. Enhances the expression of uncoupling proteins2 (UCP2) in HepG2 cells. This effect was less pronounced under hyperglycemic conditions.
A glucopyranosyl urea compound that acts as an inhibitor of muscle glycogen phosphorylase (Ki = 930 nM). Displays a mixed type of inhibition. Enhances glucose sensitivity in chow-fed, obese, diabetic mice and increasing hepatic glucose uptake. Reduces blood glucose levels and increases hepatic glycogen content in C57/BL6J mice. Shown to increase mitochondrial oxidation in Hep2G cells under normoglycemic conditions. Enhances the expression of uncoupling proteins2 (UCP2) in HepG2 cells. This effect was less pronounced under hyperglycemic conditions.
Please note that the molecular weight for this compound is batch-specific due to variable water content.
Please note that the molecular weight for this compound is batch-specific due to variable water content.
Biochem./physiol. Wirkung
Cell permeable: yes
Primary Target
Glycogen Phosphorylase
Glycogen Phosphorylase
Reversible: yes
Verpackung
Packaged under inert gas
Warnhinweis
Toxicity: Standard Handling (A)
Rekonstituierung
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Sonstige Hinweise
Nagy, L., et al. 2013. PLoS One.8, e69420.
Rechtliche Hinweise
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Lagerklassenschlüssel
11 - Combustible Solids
WGK
WGK 3
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
Analysenzertifikate (COA)
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Lilla Nagy et al.
PloS one, 8(7), e69420-e69420 (2013-08-13)
Glycogen phosphorylase (GP) catalyzes the breakdown of glycogen and largely contributes to hepatic glucose production making GP inhibition an attractive target to modulate glucose levels in diabetes. Hereby we present the metabolic effects of a novel, potent, glucose-based GP inhibitor
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