5.00523

ASIC Channel Modulator II, GMQ

• Synonym(e): ASIC Channel Modulator II, GMQ, 2-guanidine-4-methylquinazoline, Acid-Sensing Ion Channel Modulator II
• Empirische Formel (Hill-System): C₁₀H₁₁N₅
• CAS-Nummer: 716-11-0
• Molekulargewicht: 201.23
• UNSPSC-Code: 12352200

Eigenschaften

• Assay: ≥99% (HPLC)
• Qualitätsniveau: 100
• Form: solid
• Hersteller/Markenname: Calbiochem^®
• Lagerbedingungen: OK to freeze; protect from light
• Farbe: white
• Löslichkeit: DMSO: 16.6 mg/mL
• Lagertemp.: 2-8°C

Beschreibung

Allgemeine Beschreibung

A positively charged guanidium-containing quinazoline that modulates ASIC function by blocking acid-induced maximal peak current as well as by altering ASICs pH dependence for activation and inactivation, enabling a partial, but sustained ASIC3 activation around neutral pH (4.4% of pH 5-induced peak current with 1 mM GMQ at pH 7.4), which is inhibitable by Amiloride (Cat. No. 129876). Intraplantar paw injection (10 µL 100 µM) is reported to elicit a pain response in asic3^+/+, but not asic3^-/-, mice in vivo. GMQ targeting area appears to overlap with Amiloride binding site in the pore region, but is distinct from ASIC calcium binding site.

Biochem./physiol. Wirkung

Primary Target
ASIC3

Reversible: yes

Warnhinweis

Toxicity: Standard Handling (A)

Rekonstituierung

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Sonstige Hinweise

Alijevic, O., and Kellenberger, S. 2012. J Biol Chem.287, 36059.

Sherwood, T.W., et al. 2012. Am. J. Physiol. Cell Physiol.303, C699.
Yu, Y., et al. 2010. Neuron.68, 61.

Rechtliche Hinweise

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H302 - H315 - H319 - H335
• P-Sätze: P261 - P264 - P270 - P301 + P312 - P302 + P352 - P305 + P351 + P338
• Gefahreneinstufungen: Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Zielorgane: Respiratory system
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable