374000

Helenalin, A. chamissonis ssp. foliosa

• Synonym(e): Helenalin, A. chamissonis ssp. foliosa
• Empirische Formel (Hill-System): C₁₅H₁₈O₄
• CAS-Nummer: 6754-13-8
• Molekulargewicht: 262.30
• UNSPSC-Code: 51111800
• NACRES: NA.77

Eigenschaften

• Assay: ≥95% (HPLC)
• Qualitätsniveau: 100
• Form: solid
• Hersteller/Markenname: Calbiochem^®
• Lagerbedingungen: OK to freeze; desiccated; protect from light
• Farbe: white to off-white
• Löslichkeit: DMSO: 10 mg/mL
• Versandbedingung: ambient
• Lagertemp.: −20°C
• InChI: 1S/C15H18O4/c1-7-6-10-12(8(2)14(18)19-10)13(17)15(3)9(7)4-5-11(15)16/h4-5,7,9-10,12-13,17H,2,6H2,1,3H3/t7-,9+,10-,12-,13+,15+/m1/s1
• InChIKey: ZVLOPMNVFLSSAA-XEPQRQSNSA-N

Beschreibung

Allgemeine Beschreibung

A cell-permeable anti-inflammatory sesquiterpene lactone that acts as a specific NF-κB-DNA binding inhibitor by irreversibly alkylating free sulfhydryls of the cysteine residues on the p65 subunit. Exhibits no effect against the DNA-binding activity of the homodimer of p50 subunit, nor does it affect cellular NF-κB activation/nuclear translocation or IκB dissociation/degradation. An excellent research tool for studying NF-κB-mediated biological processes both in cultures in vitro and in animals in vivo.

Verpackung

Packaged under inert gas

Warnhinweis

Toxicity: Toxic (F)

Rekonstituierung

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Sonstige Hinweise

Boulanger, D., et al. 2007. Vet. Microbiol.119, 330.
Auld, C.A., et al. 2006. Biochem. Biophys. Res. Commun.346, 314.
Huang, P.R., et al. 2005. Cancer Lett.227, 169.
Lyss, G., et al. 1998. J. Biol. Chem.273, 33508.
Lyss, G., et al. 1997. Biol. Chem.378, 951.

Rechtliche Hinweise

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Sicherheitshinweise

• Piktogramme: GHS06
• Signalwort: Danger
• H-Sätze: H301
• P-Sätze: P264 - P270 - P301 + P310 - P405 - P501
• Gefahreneinstufungen: Acute Tox. 3 Oral
• Lagerklassenschlüssel: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable