342000

Caspase Inhibitor, Negative Control

The Caspase Inhibitor, Negative Control, also referenced under CAS 105637-38-5, controls the biological activity of Caspase. This small molecule/inhibitor is primarily used for Cancer applications.

• Synonym(e): Caspase Inhibitor, Negative Control, Z-FA-FMK, Cathepsin B, Inhibitor I
• Empirische Formel (Hill-System): C₂₁H₂₃FN₂O₄
• CAS-Nummer: 105637-38-5
• Molekulargewicht: 386.42
• UNSPSC-Code: 12352200

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: solid
• Hersteller/Markenname: Calbiochem^®
• Lagerbedingungen: OK to freeze; desiccated
• Farbe: off-white
• Löslichkeit: DMSO: 10 mg/mL
• Versandbedingung: ambient
• Lagertemp.: −20°C
• InChI: 1S/C21H23FN2O4/c1-15(19(25)13-22)23-20(26)18(12-16-8-4-2-5-9-16)24-21(27)28-14-17-10-6-3-7-11-17/h2-11,15,18H,12-14H2,1H3,(H,23,26)(H,24,27)
• InChIKey: ASXVEBPEZMSPHB-UHFFFAOYSA-N

Beschreibung

Allgemeine Beschreibung

A cell-permeable, irreversible cathepsin B inhibitor that may be potentially useful in treating arthritis. Suitable as a negative control for caspase-1 inhibition studies.

A cell-permeable, irreversible cathepsin B inhibitor. Blocks LPS-induced production of IL-1α and IL-1β. Suitable as a negative control for caspase-1 and caspase-2 inhibitors because it lacks an aspartic acid residue at the P1 position.

Biochem./physiol. Wirkung

Cell permeable: yes

Primary Target
Cathepsin-B

Product does not compete with ATP.

Reversible: no

Warnhinweis

Toxicity: Standard Handling (A)

Sequenz

Z-Phe-Ala-FMK

Rekonstituierung

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Sonstige Hinweise

Schotte, P., et al. 2001. J. Biol. Chem.276, 21153.
Guo, H., et al. 1998. Exp. Cell Res.245, 57.
Rosenthal, P.J., et al. 1993. J. Clin. Invest.91, 1057.
Ahmed, N.K., et al. 1992. Biochem. Pharmacol.44, 1201.
Rauber, P., et al. 1986. Biochem. J. 239, 633.
Shaw, E., et al. 1986. Biomed. Biochim. Acta 45, 1397.
Rasnick, D. 1985. Anal. Biochem. 149, 461.

Rechtliche Hinweise

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable