23-058-M

Smurf1, active

• Synonym(e): SMAD ubiquitination regulatory factor 1, SMAD-specific E3 ubiquitin-protein ligase 1
• UNSPSC-Code: 12352202
• eCl@ss: 32160405
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: human
• Qualitätsniveau: 100
• Form: liquid
• Hersteller/Markenname: Upstate^®
• Methode(n): activity assay: suitable
• NCBI-Hinterlegungsnummer: NM_181349

Beschreibung

Allgemeine Beschreibung

Smurf1 is a member of the Nedd4-like family of E3 ligases. It contains an amino terminal C2 domain and 2 WW domains that are responsible for cellular localization and substrate recognition, and a catalytic carboxyl terminal HECT domain.
Smurf1 was originally identified as a negative regulator of the TGF-β/BMP (bone morphogenetic proteins) signalling pathway by degrading SMAD proteins and TGF-β /BMP receptors. To date, over a dozen substrates have been identified, including Runx2, MEKK2, RhoA, Par6, JunB, Talin head, Prickle1, TRAF family proteins, and STAT1. This suggests a pleiotropic role for Smurf1 in various cellular functions such as bone homeostasis, embryonic development, cell movement and polarity control, and immune response. Aberrant expression of Smurfs has been shown to occur in several types of cancers, including breast, oesophageal, pancreatic and renal cell carcinomas.

Anwendung

Ubiquitination Cascade Comoponent: E3

Physikalische Form

Purified using glutathione sepharose.

Rechtliche Hinweise

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H317
• P-Sätze: P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364
• Gefahreneinstufungen: Skin Sens. 1
• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: WGK 2
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable