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Merck
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Wichtige Dokumente

16-173

Sigma-Aldrich

Anti-FAK Antibody, clone 4.47, agarose conjugate

clone 4.47, Upstate®, from mouse

Synonym(e):

Anti-FADK, Anti-FADK 1, Anti-FAK, Anti-FAK1, Anti-FRNK, Anti-PPP1R71, Anti-p125FAK, Anti-pp125FAK

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About This Item

UNSPSC-Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

Biologische Quelle

mouse

Qualitätsniveau

100

Antikörper-Produkttyp

primary antibodies

Klon

4.47, monoclonal

Speziesreaktivität

human

Hersteller/Markenname

Upstate®

Methode(n)

immunoprecipitation (IP): suitable

NCBI-Hinterlegungsnummer

NM_005607.3
NM_153831.2

UniProt-Hinterlegungsnummer

Q05397

Versandbedingung

wet ice

Posttranslationale Modifikation Target

unmodified

Angaben zum Gen

human ... PTK2(5747)

Allgemeine Beschreibung

Anti-FAK monoclonal antibody (05-537), covalently coupled to Protein G agarose by dimethyl-pimelimidate

Anwendung

Research Category
Zelluläre Signaltransduktion
Research Sub Category
Cytoskelettale Signalübertragung
Suitable for immunoprecipitation and affinity purification.
This Anti-FAK Antibody, clone 4.47, agarose conjugate is validated for use in IP for the detection of FAK.

Leistungsmerkmale und Vorteile

Format: Gel Immobilized

Qualität

routinely evaluated by immunoprecipitating FAK from a mouse 3T3/A31 RIPA cell lysate, as confirmed by subsequent immunoblot analysis using anti-FAK (05-537)

Physikalische Form

PBS containing 0.05% sodium azide

Lagerung und Haltbarkeit

2 years at 4°C

Rechtliche Hinweise

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Lagerklassenschlüssel

12 - Non Combustible Liquids

WGK

WGK 2

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Die Dokumentenbibliothek aufrufen

Attila Aszodi et al.
Genes & development, 17(19), 2465-2479 (2003-10-03)
Beta1 integrins are highly expressed on chondrocytes, where they mediate adhesion to cartilage matrix proteins. To assess the functions of beta1 integrin during skeletogenesis, we inactivated the beta1 integrin gene in chondrocytes. We show here that these mutant mice develop
Eugene Ciccimaro et al.
Analytical chemistry, 81(9), 3304-3313 (2009-04-10)
A vital point of convergence for many signaling pathways at cellular focal adhesions is the interaction of two nonreceptor tyrosine kinases, focal adhesion kinase (FAK) and Src. The binding of Src to FAK leads to the phosphorylation of Y(576) and
Eugene Ciccimaro et al.
Molecular pharmacology, 75(3), 658-666 (2008-12-23)
A recently developed stable isotope dilution liquid chromatography-multiple reaction/mass spectrometry method to quantify focal adhesion kinase (FAK) activation loop phosphorylation was used to study endogenous Src kinase activity. This revealed that bis-phosphorylated pTyr(576)/Tyr(577)-FAK was a biomarker of Src activity and
Gabriela D'Amico et al.
Development (Cambridge, England), 149(13) (2022-06-21)
Precise vascular patterning is crucial for normal growth and development. The ERG transcription factor drives Delta-like ligand 4 (DLL4)/Notch signalling and is thought to act as a pivotal regulator of endothelial cell (EC) dynamics and developmental angiogenesis. However, molecular regulation
Elena Kurenova et al.
Cell cycle (Georgetown, Tex.), 13(16), 2542-2553 (2014-12-09)
Melanoma has the highest mortality rate of all skin cancers and a major cause of treatment failure is drug resistance. Tumors heterogeneity requires novel therapeutic strategies and new drugs targeting multiple pathways. One of the new approaches is targeting the

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